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VOLUME 8 , ISSUE 1 ( January-February, 2017 ) > List of Articles


Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients

Milton C Kuga, Mateus R Tonetto, Rafael DS Caetano, Paulo HDS Castro, Ana C Soares

Citation Information : Kuga MC, Tonetto MR, Caetano RD, Castro PH, Soares AC. Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients. World J Dent 2017; 8 (1):55-58.

DOI: 10.5005/jp-journals-10015-1411

Published Online: 01-06-2013

Copyright Statement:  Copyright © 2017; The Author(s).



This study aimed to evaluate the occurrence of radiodermatitis in patients undergoing radiotherapy in the head and neck.

Materials and methods

Thirty-eight patients were evaluated 6 months after the end of radiotherapy to treat cancer in the head and neck region. The radiodermatitis was clinically classified as absent, acute, or chronic. Data, such as age, sex, race/ color, drinking and smoking habits, number of radiotherapy sessions, and conduction of adjuvant chemotherapy were also obtained. Fisher's exact test and Pearson's test were used to analyze the correlation of the independent variables and the presence of radiodermatitis.


The mean age of the patients was 59.71 (± 10.67), and 29 (76.3%) were men, 24 (63.2%) were non-white race/ color, 28 (63.7%) were alcohol consumers, and 33 (86.8%) were smokers. The average number of radiotherapy sessions was 37.26 (± 7.66); 30 (78.9%) patients underwent chemotherapy; and 26 (68.4%) had chronic radiodermatitis. The only variable statistically related to the occurrence of radiodermatitis in the patients was smoking.


Radiodermatite was quite prevalent among the studied patients and was directly related to the smoking habit.

How to cite this article

Caetano RDS, Volpato LER, Castro PHDS, Borba AM, Aranha AMF, Kuga MC, Tonetto MR, Soares AC, Bandeca MC, Borges ÁH. Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients. World J Dent 2017;8(1):55-58.

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  1. Phase III quality-of-life study results: impact on patients’ quality of life to reducing xerostomia after radiotherapy for head-and-neck cancer – RTOG 97-09. Int J Radiat Oncol Biol Phys 2003 Jul 1;56(3):832-836.
  2. Wound healing after radiation therapy: review of the literature. Radiat Oncol 2012 Sep 24;7:162
  3. Symptom clusters in patients with head and neck cancer receiving concurrent chemoradiotherapy. Oral Oncol 2013 Apr;49(4):360-366.
  4. Radiation therapy and chemotherapy-induced oral mucositis. Braz J Otorhinolaryngol 2007 Jul-Aug;73(4):562-568.
  5. Alterações dermatológicas em pacientes oncológicos – adultos e crianças. Arq Bras Ciên Saúde. 2009;34(2):87-93.
  6. Limitation of mouth opening after radiotherapy for head and neck. Rev Gaúch Odontol 2016;64(1):24-29.
  7. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol. 2006 Jan;54(1):28-46.
  8. Usage of Calendula officinalis in the prevention and treatment of radiodermatitis: a randomized double-blind controlled clinical trial. Rev Esc Enferm USP 2015 Apr;49(2):221-228.
  9. Therapeutical potential of the phenytoin in the cicatrisation of radiotherapy lesions. Esc Anna Nery R Enferm 2007;11(1):143-149.
  10. Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13. Int J Radiat Oncol Biol Phys 2000 Dec 1;48(5):1307-1310.
  11. Traitement et prévention des radiodermitesaiguës. Cancer Radiother 2010 Jun;14(3):213-216.
  12. Prophylaxis of acute radiation dermatitis with an innovative FDA-approved two-step skin care system in a patient with head and neck cancer undergoing a platin-based radiochemotherapy: a case report and review of the literature. Dermatology. Dermatology 2013;227(2): 171-174.
  13. Skin toxicity during breast irradiation: pathophysiology and management. South Med 2004 Oct;97(10):989-993.
  14. Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: a pilot study. Br J Radiol 2014 Jun;87(1038):20130490.
  15. Epidemiologic evaluation of head and neck patients in a university hospital of Northwestern São Paulo State. Braz J Otorhinolaryngol 2008 Jan-Feb;74(1):68-73.
  16. Quality of life of patients with head and neck cancer. Braz J Otorhinolaryngol 2013 Jan-Feb;79(1):82-88.
  17. Nutritional profile of cancer patients attended in ambulatory of head and neck of the philanthropic hospital in Cuiabá (MT), Brazil. Arch Health Invest 2014;3(3):76-83.
  18. Prevention and control of sequels in the mouth of patients treated with radiation therapy for head and neck tumors. Radiol Bras 2005;38(2):107-115.
  19. Predictive factors for late normal tissue complications following radiotherapy for breast cancer. Breast Cancer Res Treat 2007 Nov;106(1):143-150.
  20. Smoking as an independent risk factor for severe skin reactions due to adjuvant radiotherapy for breast cancer. Breast 2013 Oct;22(5):634-638.
  21. Perioperative abstinence from cigarettes: physiologic and clinical consequences. Anesthesiology 2006 Feb;104(2):356-367.
  22. High rate of severe radiation dermatitis during radiation therapy with concurrent cetuximab in head and neck cancer: results of a survey in EORTC institutes. Radiother Oncol 2009 Feb;90(2):166-171.
  23. Factors influencing the severity of radiation skin and oral mucosal reactions: development of a conceptual framework. Eur J Cancer Care 2002 Mar;11(1):33-43.
  24. RTOG criteria to evaluate acute skin reaction and its risk factors in patients with breast cancer submitted to radiotherapy. Rev Lat Am Enfermagem 2008 Sep-Oct;16(5):844-849.
  25. Prevention and treatment of acute radiationinduced skin reactions: a systematic review and meta-analysis of randomized controlled trials. BMC Cancer 2014 Jan 31;14:53
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