Aim: To assess the efficacy of two different periodontal dressing materials on Porphyromonas gingivalis (P. gingivalis) count and patient satisfaction following periodontal flap surgery. Materials and methods: A randomized split-mouth study was conducted in which 11 patients diagnosed with generalized chronic periodontitis undergoing periodontal flap surgery were selected based on inclusion and exclusion criteria. Three quadrants were selected in each patient: in the first quadrant, only sutures were placed; in the second quadrant, sutures were followed by Coe-Pak™; and in the third quadrant, only Xoin cyanoacrylate adhesive was applied. In all three groups, P. gingivalis colony-forming units (CFU) were compared at baseline and at the 7-day follow-up. Additionally, a self-administered questionnaire was completed by the patients for all three groups, and pain levels were evaluated using the numeric pain scale (by Caffery et al., 1989). Results: There was a statistically significant decrease in CFU count in all three groups on the 7th day (p = 0.001), with a greater decline in the Xoin cyanoacrylate group (mean difference = 1,254.2). Furthermore, there was no or minimal pain in the Xoin group, indicating a significant reduction in pain (p = 0.001), followed by the Coe-Pak™ group and the suture group. Conclusion: Xoin cyanoacrylate has emerged as a newer tissue adhesive that is painless, biocompatible, and offers better tissue handling, reduced time consumption, and greater patient acceptability after periodontal flap surgery. Moreover, it helps achieve hemostasis after surgery. Clinical significance: Placing periodontal dressings can prevent wound contamination and promote rapid healing. The most commonly available periodontal dressing is Coe-Pak™, highlighting the need for more such dressings.