Aim and objective: To analyze various factors related to fallouts of patients undergoing multi-visit root canal therapy (RCT) and the pattern of demand for endodontic treatment in the adult population attending a tertiary health care facility. Materials and methods: A retrospective analysis of the hospital records of patients who attended the Department of Dentistry from July to March 2020 for multi-visit RCT was done. Records of 362 patients were studied at four different stages of multi-visit RCT. The clinical and demographic data were collected. Data regarding age, gender, tooth type, and jaw type were also collected and analyzed using SPSS software. Results: There were 362 patients, comprising 226 (62.43%) females and 136 (37.57%) males. A total of 401 teeth were treated. The highest incidence of endodontic disease (35.64%) was seen in the 20–29 years age-group. The maximum number of patients discontinued further treatment following the biomechanical preparation stage. First molars were the most frequently treated tooth type, whereas mandibular lateral incisors were the least commonly treated. Conclusion: More females compared to the male population and a younger age-group demanded RCT. Finally, only 25% of patients completed the treatment. Clinical significance: The research findings indicate a need to promote awareness among people regarding treatment compliance. Also, the findings of the study provide a deeper insight into understanding the needs of people in the area, along with the existing barriers to maintaining regular follow-ups. This holds significant value in designing future preventive strategies and treatment plans in the present setup.