Citation Information :
Banthia K, Baxi M, Bhagat D, Bihare S, Rathod S, Bawankar PV, Makhne-Shelke U. Comparative Evaluation of Effect of Syzygium Cumini Seed Extracts and Psidium Guajava Leaf Powder against Periodontal Pathogens: An In Vitro Study. World J Dent 2024; 15 (6):477-482.
Aim: This study aimed to evaluate the minimum inhibitory concentration (MIC) of Syzygium cumini (jambolina) seed extract and Psidium guajava (guava) leaf extract against Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), and Aggregatibacter actinomycetemcomitans (Aa).
Materials and methods: The preparation of the herbal aqueous extracts and alcohol extracts was done by Soxhlet extraction method. MIC of different extracts of S. cumini and Psidium guajava was determined.
Results: The MIC of aqueous Psidium guajava leaf extract for Aa was 100 μg/mL, for Tf was 6.25 μg/mL, and Pg was sensitive at all concentrations. The MIC of the aqueous extract of S. cumini was 25 μg/mL for Aa, 12.5 μg/mL for Tf, and Pg was sensitive at all concentrations. The MIC of alcoholic extract of Psidium guajava and S. cumini was found to be 100 μg/mL for Aa and 1.6 μg/mL for Tf.
Conclusion: The S. cumini seed extract and Psidium guajava leaf extract showed antibacterial activity against periodontopathogen species Aa, Tf, and Pg. The MIC for the species examined, however, ranged widely and were often very high. Traditional knowledge may nevertheless offer some insights into probable candidates for the creation of new antibiotics in the future.
Clinical significance: Peri-pathogens are responsible for periodontitis. The present herbal extracts could be used as antimicrobial agents to eradicate or minimize the bacterial load in dental plaque and be used for oral hygiene maintenance.
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