World Journal of Dentistry

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VOLUME 15 , ISSUE 5 ( May, 2024 ) > List of Articles

ORIGINAL RESEARCH

Comparative Evaluation of Gingival Crevicular Fluid Sulfiredoxin Levels in Patients with Periodontitis Prior and after Periodontal Therapy: A Prospective Clinical Trial

Karthikeyan Murthy Kumar, Sheeja Varghese, Selvaraj Jayaraman, Dhanraj Ganapathy, Mohmed Isaqali Karobari

Keywords : Chronic periodontitis, Gingival crevicular fluid, Oxidative stress, Reactive oxygen species, Sulfiredoxin

Citation Information : Kumar KM, Varghese S, Jayaraman S, Ganapathy D, Karobari MI. Comparative Evaluation of Gingival Crevicular Fluid Sulfiredoxin Levels in Patients with Periodontitis Prior and after Periodontal Therapy: A Prospective Clinical Trial. World J Dent 2024; 15 (5):394-400.

DOI: 10.5005/jp-journals-10015-2400

License: CC BY-NC 4.0

Published Online: 28-06-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Aim: To evaluate the gingival crevicular fluid (GCF) sulfiredoxin (SRXN1) levels among patients with chronic periodontitis (CP) and healthy controls and to compare the two groups 1 month following nonsurgical periodontal therapy. Materials and methods: A total of 30 participants were allocated into two groups based on specific inclusion criteria—(1) group I, consisting of 15 individuals with periodontal health, and (2) group II, comprising 15 patients diagnosed with stage II grade B periodontitis. After a thorough clinical examination, GCF was obtained from both groups, and nonsurgical periodontal therapy was performed. After 1 month, a follow-up involved collecting GCF from both groups for subsequent analysis. SRXN1 levels in the collected samples were assessed using the enzyme-linked immunosorbent assay (ELISA) test. Results: Gingival crevicular fluid SRXN1 levels in the control group were 8.2946 ± 0.7081pg/mL, whereas, in periodontitis patients, it was 8.5323 ± 0.7016 pg/mL, which had no significant difference (p = 0.36). After nonsurgical periodontal therapy, a slight increase in GCF SRXN1 levels (8.8475 ± 0.8281 pg/mL) was observed compared to baseline among periodontitis patients was statistically insignificant (p = 0.18), whereas, in the control group, there was a reduction in GCF SRXN1 levels from a baseline to 1-month follow-up after nonsurgical periodontal therapy (p = 0.021). Conclusion: The present study's findings suggest that there is no notable difference in the levels of SRXN1 in GCF between individuals with CP and healthy controls. Moreover, no significant correlation was observed between GCF SRXN1 levels and clinical parameters. Clinical significance: The findings of this research underscore the potential utility of SRXN1 as a biomarker that facilitates the analysis of prognosis, clinical treatment response, and correlation in periodontal health and disease.


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