Citation Information :
Kulkarni VV, Parandekar SP, Ranade RS, Kulkarni PV. Analysis of Serum Lactate Dehydrogenase Levels among Tobacco Users with No Oral Lesions: A Cross-sectional Study. World J Dent 2024; 15 (4):298-302.
Aim: The aim of the study was to evaluate serum lactate dehydrogenase (LDH) levels in tobacco users without oral lesions.
Materials and methods: The study involved a total of 20 subjects, ranging in age from 18 to 60 years, divided into four groups based on tobacco use habits, group I—tobacco chewers, group II—tobacco smokers, group III—individuals who both smoked and chewed tobacco, and group IV (control)—healthy individuals with no history of tobacco use (control group). Participants were selected based on a minimum of 6 months of tobacco use without oral mucosal lesions. Medically compromised patients and those with a history of cancer treatment were excluded from the study. Serum LDH levels were evaluated using a blood sample collected via venipuncture from the antecubital vein. The sample was processed by centrifugation to separate the serum, which was then analyzed for LDH levels within 2 hours of collection. Serum LDH levels across different groups of tobacco users and healthy controls were evaluated and compared using statistical analysis.
Results: The mean serum LDH levels were compared among four groups. The mean LDH levels for each group were group I (tobacco chewers): 198.17 U/L; group II (tobacco smokers): 225.11 U/L; group III (tobacco chewers and smokers): 217.22 U/L, and group IV (control group): 165.69 U/L. Analysis of variance (ANOVA) analysis revealed a significant statistical difference (p < 0.05) among the four groups. The serum LDH levels were higher in tobacco users than in healthy controls. The serum LDH levels were higher in tobacco smokers than in tobacco chewers. The mean LDH levels were significantly greater in group III (tobacco chewers and smokers) compared to the control group (group IV).
Conclusion: The study findings indicated that tobacco use is associated with elevated serum LDH levels with the highest levels observed in individuals who both smoke and chew tobacco.
Clinical significance: This research on LDH levels sought to address the importance of early detection of cancer-related changes at the cellular level in tobacco users to combat the menace of oral cancer. Serum LDH levels can also be used to motivate tobacco users to quit their tobacco habit.
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