Aim: To evaluate and compare the clinical and antibacterial efficacy of plain vicryl suture material and triclosan-coated vicryl suture material in extraction sockets. Materials and methods: A total of 12 patients (24 extraction sites) who were indicated for bilateral orthodontic extraction of first premolars were enrolled in the study. The extraction on the right side and left side of the first premolar teeth was carried out and sutured with triclosan-coated vicryl (3-0) suture with a round body needle on the right side and plain vicryl (3-0) suture with round body needle on the left side. While placing the suture, ease of handling of both suture materials was assessed. Postoperatively, on day 3, soft tissue healing and suture site infection were studied. On day 7, sutures were removed from extraction sites and sent for microbiological evaluation and healing, and suture site infections were assessed. Results: The results obtained from the study suggest that there was a statistically significant difference between both suture materials in terms of soft tissue healing. But statistically, there was no significant difference between both suture materials in terms of intraoperative handling, suture site infection (SSI), and bacterial colonization. Between the right and left sides, there was a statistically significant difference, with mean ranks of 16.5 and 8.5 on day 3 (p-value = 0.005) and 17.25 and 7.75 on day 7. On the basis of the quantitative assessment, there was a substantial reduction in adherence of bacteria on the right side compared to the left side. Conclusion: This study concluded that triclosan-coated vicryl suture has a promising potential in preventing the colonization of bacteria around the extraction area. Triclosan-coated vicryl suture reduces suture site infection and enhances soft tissue healing. Clinical significance: The clinical significance of this study lies in its potential to inform dental practitioners about the efficacy of triclosan-coated vicryl suture material compared to plain vicryl suture material in extraction socket healing. If the study demonstrates that triclosan-coated vicryl suture material leads to better clinical outcomes and reduced bacterial colonization in extraction sockets, it could influence clinical practice by encouraging the use of this coated suture material for better patient outcomes, reduced risk of infection, and improved wound healing. Additionally, the comparison of the two materials in a split-mouth study design provides valuable insights into their relative effectiveness within the same patient, minimizing confounding variables and enhancing the reliability of the findings.