Aim: To evaluate the canal centering ability of two heat-treated single-shaping nickel-titanium (NiTi) rotary files in simulated severely curved canals. Materials and methods: Standardized 40 resin blocks with 35° simulated curved canals were randomly divided into two groups according to the instrumentation systems, group I: TruNatomy (n = 20) and group II: XP-endo Shaper (n = 20). Before instrumentation, the resin blocks with an endodontic ruler fixed were photographed in a standardized setup at a magnification ratio (1:4). The simulated canals were instrumented according to the manufacturer's instructions for each system and irrigated in-between with normal saline. After instrumentation, resin blocks were photographed in the same preinstrumentation setup. The pre- and postinstrumentation images stored in JPEG format were sketched with Adobe Photoshop software CS5 using the filter “sketch” (green and red color, respectively). They were superimposed using the same software, and on the canal profile, 5 points of measurement were traced at 1, 2, 3, 5, and 7 mm from the apex representing the apical, middle, and coronal third, respectively. The mean canal centering ratio (CR) was compared for both groups at all the levels of measurement using a nonparametric Mann–Whitney U test. Intergroup and intragroup multiple comparisons of the mean canal CR at each of the measuring points against all the measuring points were conducted using the post hoc Tukey test. Results: The results showed that no significant statistical difference was evident within the same group and between the two groups at all the points of measurement (p > 0.05). Conclusion: TruNatomy and XP-endo Shaper showed comparable canal centering ability in severely curved canals. Clinical significance: These heat-treated single shaping files would thus empower the clinicians to adhere to the ultraconservative access designs, while achieving an adequate and predictable apical preparation within a shorter duration of time.