Aim: To evaluate patient-perceived postcementation sensitivity of class II metal inlays cemented using resin-modified glass ionomer (RMGI) and self-adhesive resin luting cement preoperatively, immediately after cementation, 1 week, and 1 month after cementation. Materials and methods: A total of 40 posterior teeth in patients aged between 20 and 50 years were selected and divided randomly into two groups of 20 each. Cast gold inlay restorations were fabricated and cemented with two different luting cements. The adapted criteria to measure the sensitivity of teeth were an objective examination for sensitivity using compressed air, cold water, and biting pressure tests. The data collected were evaluated using the student t-test with p < 0.05 as the level of significance. Results: The patients with restorations cemented with self-adhesive resin luting cement demonstrated less postoperative sensitivity when compared with RMGI luting cement with all three tests used. This difference was nonsignificant (p > 0.05) when compressed air and bite test were used and was significant (p < 0.05) when cold water was used immediately and 1 week after inlay cementation. Conclusion: The patients having restorations cemented with self-adhesive resin cement (SARC) revealed the least postoperative sensitivity at all the time intervals assessed by different tests. Clinical significance: Postcementation hypersensitivity is a common complaint with indirect restorations therefore its cementation with good luting cement is of paramount importance in clinical dentistry.