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VOLUME 13 , ISSUE S2 ( Supplementary Issue 2, 2022 ) > List of Articles

ORIGINAL RESEARCH

Oxygen-releasing Gel vs 0.2% Chlorhexidine Gel as an Adjuvant to Scaling and Root Planing: A Randomized Controlled Trial

Shweta Bali, Shobhit Arora, Priyanka Aggarwal, Aruna Nautiyal, Deepali Singhal

Keywords : Chlorhexidine, Chronic periodontitis, Local drug delivery, Nonsurgical periodontal treatment, Oxygen-releasing gel

Citation Information :

DOI: 10.5005/jp-journals-10015-2137

License: CC BY-NC 4.0

Published Online: 31-12-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Aim: To compare and evaluate oxygen-releasing gel vs 0.2% chlorhexidine (CHX) gel as an adjuvant to scaling and root planning (SRP). Materials and methods: A total of 11 patients (22 sites) with chronic periodontitis were randomly assigned into test and control groups by the flip of a coin method. Pre-op clinical parameters recorded were plaque index (PI), gingival index (GI), probing pocket depth (PPD), and wound healing index (WHI). Post-completion of SRP, test group (n = 11) received subgingival delivery of oxygen-releasing gel and control group (n = 11) received 0.2% CHX gel. A periodontal pack and oral hygiene instructions (OHI) were given. Post-op clinical parameters were measured at 1 and 3 months. Results: The intergroup comparison of test sites (oxygen-releasing gel) with the control sites (0.2% CHX gel) showed a statistically higher significant reduction in test group when compared to control group in periodontal parameters such as PPD (p < 0.0001), clinical attachment level (CAL) (p < 0.0001), WHI (p, 0.0001). However, no statistically significant difference was found in PI and GI between both groups. Conclusion: Oxygen-releasing gel, when used as a local drug delivery, showed better results when compared to the current gold standard, that is, 0.2% CHX gel in the nonsurgical management of moderately deep pockets in chronic periodontitis. Clinical significance: Nonsurgical periodontal therapy lays the foundation for most periodontal procedures. It also stands a chance of higher acceptability to the patients. Hence, whenever the clinical situation is conducive, oxygen-releasing gel serves to be an excellent local drug delivery alternative.


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  1. Newmann MG, Takei HH, Carranza FA. Clinical Periodontology. 10th ed. Philadelphia. 2002.
  2. Lendhey S, Kale T, Seth T, et al. Effect of subgingival application of ozone oil versus olive oil as an adjunct to scaling and root planing in chronic periodontitis: a clinical and microbiological study. J Oral Res Rev 2002;12(2):63–69. DOI: 10.4103/jorr.jorr_23_19
  3. Koul A, Kabra R, Chopra R, et al. Comparative evaluation of oxygen releasing formula (blue-m gel®) and chlorhexidine gel as an adjunct with scaling and root planing in the management of patients with chronic periodontitis –a clinico microbiological study. J Dent Specialities 2019;7(2):111–117. DOI: 10.18231/j.jds.2019.026
  4. Unsal E, Akkaya M, Walsh TF. Influence of a single application of subgingival chlorhexidine gel or tetracycline paste on the clinical parameters of adult periodontitis patients. J Clin Periodontol 1994;21(2):351–355. DOI: 10.1111/j.1600-051x.1994.tb00725.x
  5. Singhla R, Tevatia S, Chaudary S, et al. Comparative evaluation of the efficacy of locally delivered 0.1% curcumin irrigation, meswak irrigation, and 0.2% CHX irrigation in management chronic periodontitis patients. J Dent Specialities 2017;5(1):53–57. DOI: 10.18231/2393-9834.2017.0013
  6. Johannsen A, Tellefsen M, Wikesjö U, et al. Local delivery of hyaluronan as an adjunct to scaling and root planing in the treatment of chronic periodontitis. J Periodontol 2009;80(9):1493–1497. DOI: 10.1902/jop.2009.090128
  7. Goodson JM, Offenbacher S, Farr DH, et al. Periodontal disease treatment by local drug delivery. J Periodontol 1985;56(5):265-272. DOI: 10.1902/jop.1985.56.5.265. PMID: 3891959.
  8. Kumar AJ, Reddy BVR, Chava VK. Effect of chlorhexidine chip in the treatment of chronic periodontitis. J Nat Sci Biol Med 2014;5(2):268–272. DOI: 10.4103/0976-9668.136159
  9. Vaish S, Dodwad V, Mahajan A, et al. Evaluation of efficacy of 0.2% chlorhexidine irrigation, 1.5% chlorhexidine chip as an adjunct to scaling and root planing in the management of chronic periodontitis. J Dent specialities 2016;4(2):142–146. DOI: 10.18231/2393-9834.2016.0009
  10. Pandya DJ, Manohar B, Mathur LK, et al. Comparative evaluation of two subgingival irrigating solutions in the management of periodontal disease: a clinicomicrobial study. J Indian Soc Periodontol 2016;20(6):597–602. DOI: 10.4103/jisp.jisp_328_16
  11. Lin K, Takesh T, Lee JH, et al. Effects of a dental gel over 6 months on periodontal health in subjects with stage II and III (mild and moderate) periodontitis. J Dent Oral Sci 2019;1(3):DOI: 10.37191/Mapsci-2582-3736-1(3)-019
  12. Verma R, Indurkar MS, Ozone versus chlorhexidine treatment of chronic periodontitis. Indian J Res 2019;8(6):148–152. DOI: 10.36106/paripex
  13. Gaggl AJ, Rainer H, Grund E, et al. Local oxygen therapy for treating acute necrotizing periodontal disease in smokers. J Periodontol 2006;77(1):31–38. DOI: 10.1902/jop.2006.77.1.31
  14. Piruat JI, López-Barneo J. Oxygen tension regulates mitochondrial DNA-encoded complex I gene expression. J Biol Chem 2005;280(52):42676–42684. DOI: 10.1074/jbc.M507044200
  15. Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol 2014;9:47–71. DOI: 10.1146/annurev-pathol-012513-104720
  16. Rodriguez PG, Felix FN, Woodley DT, et al. The role of oxygen in wound healing: a review of the literature. Dermatol Surg 2008;34(9):1159–1169. DOI: 10.1111/j.1524-4725.2008.34254.x
  17. Kalliainen LK, Gordillo GM, Schlanger R, et al. Topical oxygen as an adjunct to wound healing: a clinical case series. Pathophysiology 2003;9(2):81–87. DOI: 10.1016/s0928-4680(02)00079-2
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