Aim: To assess the effect of essential oil intraoral spray for dry mouth. Composition of spray: essential oil (peppermint oil 1 mL), propolis (1.5 mL), xylitol (700 mg), ethyl alcohol (10 mL), and water (up to 50 mL). Materials and methods: A total of 30 patients with dry mouth symptoms were selected for the study (study group). Clinical parameters such as gingival index, plaque index, and visual analog scale (VAS) for xerostomia and desensitization were recorded. A total of 30 patients were selected for control group. Two intraoral sprays were formulated one for each group. The results of both groups were then analyzed. Results: Statistical difference was obtained in the various parameters between the two groups. Mean gingival index (GI) score in control group at baseline was found to be 0.489 + 1.242 and postoperative it was 0.271 + 0.109. There was a statistically significant difference in mean GI score between baseline and postoperative at 5% significance level (p = 0.001). Mean salivary rate (SR) score in control group at baseline was found to be 2.400 + 1.242 and postoperative it was 2.066 + 0.961. There was no statistically significant difference in mean SR score between baseline and postoperative at 5% significance level (p = 0.298). Conclusion: Essential oil and propolis spray are effective in improving oral health of patients suffering from dry mouth and dentinal hypersensitivity. It also ensured better patient compliance. Hence, encouraged them to use as prescribed. Clinical significance: Essential oil intraoral spray has all the advantages of promoting oral health by treating xerostomia, dentinal hypersensitivity, and less plaque accumulation; thus, improving the overall health.