Citation Information :
Gogoi A, Batra P, Preeja C, Nisha K. Comparative Evaluation of the Efficacy of Pro-Argin-containing Desensitizing Toothpaste vs Mouthwash: An In Vitro Study. World J Dent 2022; 13 (S1):S81-S86.
Aim: The aim of this study was to evaluate if Pro-Argin mouthwash is as efficient as Pro-Argin paste at occluding dentinal tubules and reducing dentin hypersensitivity (DH).
Materials and methods: The study used 90 dentin disks that were free of enamel and pulp horns. They were divided into three groups of 30 disks each at random: group I: saline-immersed dentin disks, group II: paste-immersed dentin disks, and group III: mouthwash-immersed dentin disks. On the 1st, 15th, and 30th days, specimens from three groups underwent scanning electron microscopic analysis.
Results: The lower the occlusion score, the fewer the open dentinal tubules and the better the tubule occlusion. The mean intergroup occlusion scores for the paste and mouthwash groups on days 1, 15, and 30 showed significantly higher dentinal tubule occlusion than the saline group at p < 0.001. The intragroup comparison of mean dentinal tubule occlusion scores on days 1, 15, and 30 using the repeated measures analysis of variance (ANOVA) test revealed no significant differences between time intervals in each study group.
Conclusion: The study found that using Pro-Argin mouthwash to occlude dentinal tubules can be a viable option for reducing hypersensitivity.
Clinical significance: When translated into clinical practice, this finding can be especially beneficial to patients recovering from periodontal surgery, where brushing with a paste is not recommended in the first postoperative week.
Holland GR, Narhi MN, Addy M, et al. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontol 1997;24(11):808–813. DOI: 10.1111/j.1600-051x.1997.tb01194.x
Sanz M, Addy M. Group D summary. J Clin Periodontol 2002;29(s3):195–196. DOI: 10.1034/j.1600-051X.29.s3.19.x
Chabanski MB, Gillam DG, Bulman JS, et al. Prevalence of cervical dentin sensitivity in a population of patients referred to a specialist periodontology department. J Clin Periodontol 1996;23(11):989–992. DOI: 10.1111/j.1600-051x.1996.tb00525.x
Al-Sabbagh M, Brown A, Thomas MV. In-office treatment of dentinal hypersensitivity. Dent Clin North Am 2009;53(1):47–60. DOI: 10.1016/j.cden.2008.11.003
Schuurs AH, Wesselink PR, Eijkman MA, et al. Dentists’ views on cervical hypersensitivity and their knowledge of its treatment. Endod Dent Traumatol 1995;11(5):240–244. DOI: 10.1111/j.1600-9657.1995.tb00496.x
Sheiham A, Maizels JE, Cushing AM. The concept of need in dental care. Int Dent J 1982;32(3):265–270.
Kleinberg I. SensiStat. A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain. Dent Today 2002;21(12):42–47.
Mello SV, Arvanitidou E, Stranick MA, et al. Mode of action studies of a new desensitizing mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride. J Dent 2013;41 Suppl 1:S12–S19. DOI: 10.1016/j.jdent.2012.11.001
Elías Boneta AR, Galán Salás RM, Mateo LR, et al. Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study. J Dent 2013;41 Suppl 1:S34–S41. DOI: 10.1016/j.jdent.2012.11.004
Al-Sabbagh M, Beneduce C, Andreana S, et al. Incidence and time course of dentinal hypersensitivity after periodontal surgery. Gen Dent 2010;58(1):e14–e19.
Davies M, Paice EM, Jones SB, et al. Efficacy of desensitizing dentifrices to occlude dentinal tubules. Eur J Oral Sci 2011;119(6):497–503. DOI: 10.1111/j.1600-0722.2011.00872.x
Penmetsa GS, Kollati P, Dwarakanath CD. Comparative evaluation of the efficacy of Novamin and Pro-Argin in reducing dentinal hypersensitivity: a double blind randomized controlled clinical trial. J Adv Med Dent Scie Res 2016;4(3):14–20.
Brännström M. Sensitivity of dentin. Oral Surg Oral Med Oral Pathol 1966;21(4):517–526. DOI: 10.1016/0030-4220(66)90411-7
Brannstrom M. The hydrodynamic theory of dentinal pain: sensation in preparations, caries, and the dentinal crack syndrome. J Endod 1986;12(10):453–457. DOI: 10.1016/S0099-2399(86)80198-4
Yoshiyama M, Masada J, Uchida A, et al. Scanning electron microscopic characterization of sensitive vs. insensitive human radicular dentin. J Dent Res 1989;68(11):1498–1502. DOI: 10.1177/00220345890680110601
West NX, Seong J, Davies M. Management of dentin hypersensitivity: efficacy of professionally and self-administered agents. J Clin Periodontol 2015;42 Suppl 16:S256–S302. DOI: 10.1111/jcpe.12336
Grover V, Kumar A, Jain A, et al. ISP good clinical practice recommendations for the management of dentin hypersensitivity. J Indian Soc Periodontol 2022;26(4):307–333. DOI: 10.4103/jisp.jisp_233_22