Citation Information :
Chaitanya PK, Penmetsa GS, Gottumukkala SN, Ramesh KS, Kumar PM, Meghana KM. Evaluation of Clinical and Microbiological Outcomes of Photodynamic Therapy-assisted Flap Surgery in Stages II and III, with Grades B and C Periodontitis: A Prospective Clinical Trial. World J Dent 2022; 13 (S1):S66-S71.
Aim: To evaluate and compare the efficacy of surgical periodontal therapy (SurgPT) in conjunction with photodynamic-assisted surgery (PTAS) with SurgPT alone.
Materials and methods: A total of 13 participants with stages II and III, with grades B and C periodontitis and contralateral probing pocket depths (PPD) ≥5 mm on at least two adjacent teeth, were randomly assigned to PTAS and SurgPT groups. Plaque index (PI), gingival index (GI), PPD, and clinical attachment level (CAL) were measured at baseline, 3, and 6 months. Red complex bacteria levels were measured using polymerase chain reaction (PCR) at baseline and 3 months.
Results: All clinical parameters were reduced significantly in both groups. Intergroup comparison revealed that the PTAS group had a considerably higher PI and GI decrease. However, the difference in reduction of PPD and CAL was not significant at given time intervals. At 3 months, PCR evaluation showed a decrease in levels of red complex bacteria with no intergroup differences.
Conclusion: Both the PTAS and SurgPT showed definitive improvement in all parameters. PTAS using indocyanine green (ICG) yielded a resolution of PI and GI, which can be attributed to the antimicrobial photodynamic therapy (PDT).
Clinical significance: PTAS may be a safe alternative for systemic antibiotics in combination with SurgPT for the management of chronic periodontitis.
Oswal S, Dwarakanath CD. Relevance of gingival crevice fluid components in assessment of periodontal disease—a critical analysis. J Indian Soc Periodontol 2010;14(4):282–286. DOI: 10.4103/0972-124X.76927
Soukos NS, Goodson JM. Photodynamic therapy in the control of oral biofilms. Periodontol 2000 2011;55(1):143–166. DOI: 10.1111/j.1600-0757.2010.00346.x
Konopka K, Goslinski T. Photodynamic therapy in dentistry. J Dent Res 2007;86(8):694–707. DOI: 10.1177/154405910708600803
Srikanth K, Chandra RV, Reddy AA, et al. Effect of a single session of antimicrobial photodynamic therapy using indocyanine green in the treatment of chronic periodontitis: a randomized controlled pilot trial. Quintessence Int 2015;46(5):391–400. DOI: 10.3290/j.qi.a33532
Cadore UB, Reis MBL, Martins SHL, et al. Multiple sessions of antimicrobial photodynamic therapy associated with surgical periodontal treatment in patients with chronic periodontitis. J Periodontol 2019;90(4):339–349. DOI: 10.1002/JPER.18-0373
Allison RR, Bagnato VS, Cuenca R, et al. The future of photodynamic therapy in oncology. Future Oncol 2006;2(1):53–71. DOI: 10.2217/14796618.104.22.168
Caton JG, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and peri-implant diseases and conditions—introduction and key changes from the 1999 classification. J Clin Periodontol 2018;89(1):S1–S8. DOI: 10.1111/jcpe.12935
Loe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontol Scand 1963;21:533–551. DOI: 10.3109/00016356309011240
Silness J, Loe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121–135. DOI: 10.3109/00016356408993968
Heitz-Mayfield LJ, Trombelli L, Heitz F, et al. A systematic review of the effect of surgical debridement vs non-surgical debridement for the treatment of chronic periodontitis. J Clin Periodontol 2002;29(3):92–102. DOI: 10.1034/j.1600-051x.29.s3.5.x
Bundidpun P, Srisuwantha R, Laosrisin N. Clinical effects of photodynamic therapy as an adjunct to full-mouth ultrasonic scaling and root planing in treatment of chronic periodontitis. Laser Ther 2018;27(1):33–39. DOI: 10.5978/islsm.18-OR-03
Meisel P, Kocher T. Photodynamic therapy for periodontal diseases: state of the art. J Photochem Photobiol B 2005;79(2):159–170. DOI: 10.1016/j.jphotobiol.2004.11.023
Al-Hamoudi N, Mokeem S, Shafqat SS, et al. Effectiveness of antimicrobial photodynamic therapy as an adjunct to open flap debridement in patients with aggressive periodontitis. Photodiagnosis Photodyn Ther 2021;33:102075. DOI: 10.1016/j.pdpdt.2020.102075
Martins SHL, Novaes ABJ, Taba MJ, et al. Effect of surgical periodontal treatment associated to antimicrobial photodynamic therapy on chronic periodontitis: a randomized controlled clinical trial. J Clin Periodontol 2017;44(7):717–728. DOI: 10.1111/jcpe.12744
Woodruff LD, Bounkeo JM, Brannon WM, et al. The efficacy of laser therapy in wound repair: a meta-analysis of the literature. Photomed Laser Surg 2004;22(3):241–247. DOI: 10.1089/1549541041438623
Shingnapurkar SH, Mitra DK, Kadav MS, et al. The effect of indocyanine green-mediated photodynamic therapy as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a comparative split-mouth randomized clinical trial. Indian J Dent Res 2016;27(6):609–617. DOI: 10.4103/0970-9290.199598