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VOLUME 13 , ISSUE 4 ( July-August, 2022 ) > List of Articles


Role of Bone Marrow Mesenchymal Stromal Cells (BMMSCs) in Osseointegration among Diabetic Patients with Dental Implants

Nabeeh A Al Qahtani

Keywords : Bone marrow mesenchymal stromal cells (BMMSCs), Dental implants, Diabetic patients, Osseointegration, Osteogenic potential

Citation Information : Al Qahtani NA. Role of Bone Marrow Mesenchymal Stromal Cells (BMMSCs) in Osseointegration among Diabetic Patients with Dental Implants. World J Dent 2022; 13 (4):425-431.

DOI: 10.5005/jp-journals-10015-2072

License: CC BY-NC 4.0

Published Online: 18-06-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Aim: This review aims to explore the literature regarding the potential of bone marrow mesenchymal stromal cells (BMMSCs) in enhancing the osseointegration of dental implants among diabetic patients. Background: Dental implants are a viable and popular option in oral rehabilitation. Various factors such as local, systemic, mechanical, and prosthetic factors play a crucial role in the successful osseointegration of dental implants. Diabetes mellitus (DM) is known to affect the survival of dental implants. Among the various methods developed to improve the survival rates in DM, bone marrow mesenchymal stem cells (BMMSCs) are gaining attention for their regenerative purposes. That could strengthen the osseointegration process in patients with DM. Review results: This review identified significant studies describing the effects of diabetes on stem cells and thereby affecting osseointegration. We identified studies that reported DM to have a negative impact on osseointegration of dental implants. We also found evidence that BMMSCs can improve the implant survival rate by enhancing osseointegration. Further, various methods of stem cell culture and scaffolds are discussed. Though the BMMSCs-coated implants improve implant survival rates, we could find only a few studies of stem cell-coated implants in diabetes. They show a positive result in diabetic subjects. Conclusion: Within the limitation of this comprehensive review, it can be concluded that BMMSCs enhance the osseointegration of dental implants among diabetic patients when their medical condition is wellcontrolled. Further double-blinded randomized controlled clinical trials are warranted to establish the clinical applicability of BMMSCs in dental implants in various systemic conditions. Clinical significance: Though literature supports implants in DM, many studies have proven the impaired osseointegration in DM. This review elaborates on the impactful role of BMMSCs in promoting the osseointegration of the implants placed in well-controlled diabetic patients.

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