Citation Information :
Khan W, Haragannavar V, Devaraj A, Rajanikanth B, Prasad K, Rao RS, Sowmya S, Augustine D, Patil S. An Unusual Case of Intravascular Oral Nodular Fasciitis: A Case Report/Review. World J Dent 2022; 13 (4):412-416.
Aim: The term spindle cell lesion, or tumor, is a purely descriptive one. This manuscript aims to report a rare case of nodular fasciitis (NF).
Background: Nodular fasciitis is a rapidly growing soft tissue myofibroblastic lesion that represents a tumor-like mass with low recurrence rate of 1–2%. Upto 20% of cases are reported to occur in the head and neck region but these lesions in the oral cavity are extremely rare and tend to affect children more.
Case report: Overlapping clinico-radiographic and microscopic features make NF a diagnostic challenge not only for the clinicians but for the histopathologist as well. The case reported here is unique because of its occurrence in older age-group and its location.
Conclusion: The deceptive clinical behavior coupled with nonspecific histologic features makes this lesion challenging to diagnose. Accurate diagnosis is important to avoid unnecessary and mutilating surgeries.
Clinical significance: Immunohistochemistry (IHC) panel of markers vimentin, smooth muscle actin, muscle specific actin, desmin, CD34, S-100, and Ki-67 aided in solving the diagnostic dilemma.
Haddad AJ, Avon SL, Clokie CM, et al. Nodular fasciitis in the oral cavity. J Can Dent Assoc 2001;67(11):664–667.
Hino S, Masuda I, Fukai S, et al. A case of nodular fasciitis involving the tongue. J Oral Maxillofac Surg Med Pathol 2015;27(3):377–379. DOI: 10.1016/j.ajoms.2014.05.007
Price Jr EB, Silliphant WM, Shuman R. Nodular fasciitis: a clinicopathologic analysis of 65 cases. Am J Clin Pathol 1961;35:122–136. DOI: 10.1093/ajcp/35.2.122
Mallina S, Rosalind S, Philip R, et al. Nodular fasciitis: a diagnostic dilemma. Med J Malaysia 2007;62(5):420–421.
Wood NH, Moodley A. Oral medicine case book 72: a rare case of nodular fasciitis affecting the mandibular gingiva. S Afr Dent J 2016;71(2):78–80.
Goldblum JR, Weiss SW, Folpe AL. Enzinger and Weiss's Soft Tissue Tumors E-book. Elsevier Health Sciences; 2013. p. 177–189.
Sato M, Yanagawa T, Yoshida H, et al. Sub mucosal nodular fasciitis arising within the buccal area: report of case. Int J Oral Surg 1981;10(3):210–213. DOI: 10.1016/s0300-9785(81)80055-5
Marx RE, Stern D. Oral and Maxillofacial Pathology. Chicago: Quintessence; 2003.
Stout AP. Pseudosarcomatous fasciitis in children. Cancer 1961;14(6):1216–1222. DOI: 10.1002/1097-0142(196111/12)14:6<1216::aid-cncr2820140611>3.0.co;2-w
Allen PW. Nodular fasciitis and its variants. Pathology 1972;4(1):61. DOI: 10.3109/00313027209068925
Ponce JB, De Lima HG, Esteves GG, et al. PP-intravascular fasciitis: a rare variant of nodular fasciitis in the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol 2017;123(2):e83. DOI: 10.1016/j.oooo.2016.09.221
Neville BW, Damm DD, Chi AC, et al. Oral and Maxillofacial Pathology. Elsevier Health Sciences; 2015. p. 479–482.