Aim: To evaluate the wettability of three commercially obtainable saliva substitutes on denture base materials. Materials and methods: One hundred specimens of heat-cured acrylic resin were fabricated for the purpose of recording the contact angulations of the salivary substitute on its surface. A 100 specimens were randomly allocated into one of the following four groups comprising 25 specimens each: group A: Distilled water, group B: Aqwet, group C: Wet Mouth, group D: Moi-Stir. Using dental plaster the wax specimens were subjected to investment in dental flasks. The traditional method of acrylization was performed as per the recommendations of the manufacturer to procure 100 resin specimens. The specimens were subjected to drying and visualized under the SEM to evaluate the finish. The contact angulations that were advancing/receding were assessed with a goniometer employing the dynamic contact angle evaluation. Results: The Aqwet group (72.89 ± 1.24 and 64.30 ± 3.02) displayed the lowest mean advancing/receding contact angles, in pursuit by Moi-Stir (79.12 ± 2.04 and 70.67 ± 2.41), Wet Mouth (82.28 ± 2.46 and 76.16 ± 2.70) as well as Distilled water groups (85.31 ± 3.02 and 80.24 ± 2.49). A statistical significant difference with p < 0.001 was noted amid the experimental groups. Conclusion: Within the limitations of this research, a conclusion arrived at the Aqwet group having lower advancing and receding contact angle values compared to Moi-Stir, Wet Mouth as well as Distilled water groups upon heat-cured acrylic resin. On the basis of the measurements of contact angles, Aqwet salivary substitute exhibited superior wettability of the heat-cures acrylic resins. Clinical significance: A key characteristic affecting oral ease is the wettability of the denture tissue surface by saliva coupled with complete denture retention, especially in patients affected by xerostomia. Therefore, saliva substitutes consisting of thickening agents provide longer relief, increased moistening, and lubrication of the oral surfaces, hence exhibiting good wetting of the tissue surface of the denture.