Citation Information :
Mallikarjun SA, Das S, Babu HM, Gowda MR, Naik A, Nanaiah P. Comparative Evaluation of Herpes Viruses in Chronic Periodontitis with and without Generalized Anxiety Disorder: A Clinico-microbial Study. World J Dent 2022; 13 (4):375-381.
Aim: The present study was aimed to detect, compare and correlate the presence of herpes simplex virus (HSV)—1, HSV-2, human cytomegalovirus (HCMV), and Epstein-Barr virus (EBV) in chronic periodontitis patients with and without generalized anxiety disorder (GAD).
Materials and methods: A total of 45 patients, aged 30–55 years were divided into three groups of 15 study participants each into chronic periodontitis; chronic periodontitis with GAD and those without chronic periodontitis and without GAD groups based on the inclusion criteria. Subgingival plaque samples were collected using curettes from the deepest periodontal pockets and sent in transport media containing tris–ethylene diamine tetra acetic acid (EDTA) and analyzed using multiplex polymerase chain reaction (MPCR). Statistical analysis was done using Chi-square test and Spearman's correlation analysis.
Results: The results of our study showed that there were elevated levels of HSV-1, HSV-2, EBV, and HCMV in the chronic periodontitis with GAD group as compared to the chronic periodontitis group with statistically significant difference observed only between the levels of EBV. The correlation analysis showed positive correlations between the herpes virus and the bleeding and plaque indices scores. On examining the correlation between herpes viruses, positive correlations were noticed between HSV-1 and EBV, HSV-1 and HCMV, and EBV and HCMV.
Conclusion: Positive association of herpes viruses in GAD patients in this study suggests a possibility of viral role in the etiology of chronic periodontitis.
Clinical significance: Treatment of GAD and chronic periodontitis simultaneously could reduce stress and viral load, thus contributing to down regulation of the progress of the chronic periodontitis.
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