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VOLUME 13 , ISSUE 3 ( May-June, 2022 ) > List of Articles


Clinical Assessment of the Effectiveness of Three Different Controlled-release Drugs in the Management of Chronic Periodontitis: An In vivo Study

Mohammad Jalaluddin, Shruti Shivakumar, Sandeep S Arora, Deesha Kumari, Mahesh Jayachandran, Rethi Gopakumar, Thilla S Vinothkumar

Keywords : Chronic periodontitis, Controlled release drugs, Nonsurgical therapy, Scaling and root planning

Citation Information : Jalaluddin M, Shivakumar S, Arora SS, Kumari D, Jayachandran M, Gopakumar R, Vinothkumar TS. Clinical Assessment of the Effectiveness of Three Different Controlled-release Drugs in the Management of Chronic Periodontitis: An In vivo Study. World J Dent 2022; 13 (3):234-238.

DOI: 10.5005/jp-journals-10015-2005

License: CC BY-NC 4.0

Published Online: 11-04-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Aim: The aim of the current research was to evaluate the efficiency of metronidazole gel, tetracycline fibers, and chlorhexidine chip agents in the treatment of chronic periodontitis. Materials and methods: A total of 60 healthy patients free from systemic diseases and having chronic generalized periodontitis were chosen for the purpose of this study. The subjects thus included were subjected to phase I therapy consisting of scaling and root planning performed over two visits by a single clinician, following which oral hygiene advice was rendered. A week after phase I management, the subjects were called again and re-evaluated to verify the chosen criteria. Subjects who were thus elected based on the inclusion criteria were assigned at random to one of the three investigational groups as (20 subjects in each group) Group A: Metronidazole, Group B: Tetracycline fibers, Group C: Chlorhexidine Chip. The follow-up after 1 week was regarded as the baseline appointment. Documentation of the gingival index, plaque index as well as the periodontal pocket depth (PPD) during the baseline appointment, plus after 1 month and 3 months after baseline was done and subjected to statistical analysis. Results: The highest reduction of the gingival index (GI) values was noted with the use of chlorhexidine chip (0.88 ± 0.07 and 0.82 ± 0.11) in pursuit by tetracycline fibers (0.96 ± 0.13 and 0.88 ± 0.10) plus the metronidazole investigational group (1.02 ± 0.04 and 0.98 ± 0.10), respectively. Highest reduction of the PI values was noted with the use of tetracycline fibers (0.82 ± 0.14 and 0.76 ± 0.02) in pursuit by chlorhexidine chip (0.88 ± 0.18 and 0.94 ± 0.06) as well as metronidazole investigational group (1.18 ± 1.08 and 1.06 ± 0.21), respectively. The greatest reduction in PPD from 5.78 ± 0.14 to 3.14 ± 0.10 was noted with use of tetracycline fibers. Conclusion: The current research, amid its limitations arrived at a conclusion that although a thorough scaling as well as root planning (SRP) is efficient in managing consistent periodontal pockets, superior results can be attained by employing topically delivered metronidazole gel, tetracycline fibers as well as chlorhexidine chips as adjuncts to the management strategy employed. Clinical significance: Multiple chemical substances may be utilized subgingivally as a management strategy to augment the efficiency of nonsurgical mechanical periodontal treatment. Topical drug delivery systems into the periodontal pocket show potential as a treatment strategy to attain superior clinical results when employed as an adjunctive form of therapy to the traditional nonsurgical periodontal management techniques. Rigorous research labors at this time, concentrate on evolution of novel techniques for efficient management.

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