World Journal of Dentistry

Register      Login

VOLUME 12 , ISSUE 4 ( July-August, 2021 ) > List of Articles

ORIGINAL RESEARCH

Comparative Evaluation of N-Butyl Cyanoacrylate with Braided Silk Suture after Periodontal Flap Surgery: A Randomized Controlled Trial

Sourav Chandra, Pratibha Shashikumar, Swet Nisha

Keywords : Cyanoacrylates, Flap surgery, Silk sutures, Tissue adhesives

Citation Information : Chandra S, Shashikumar P, Nisha S. Comparative Evaluation of N-Butyl Cyanoacrylate with Braided Silk Suture after Periodontal Flap Surgery: A Randomized Controlled Trial. World J Dent 2021; 12 (4):328-332.

DOI: 10.5005/jp-journals-10015-1847

License: CC BY-NC 4.0

Published Online: 15-07-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim and objective: This clinical study was carried out to compare the efficacy of N-butyl cyanoacrylate with braided silk sutures after a periodontal flap surgery in terms of wound healing, postoperative pain experienced by study subjects, and the time required for completion of flap closure. Materials and methods: Forty patients with moderate to severe generalized periodontitis were divided into two treatment groups. Test group (N-butyl cyanoacrylate) and control group (3-0, braided silk sutures). Wound healing, postoperative pain experienced by study subjects, and the time required for completion of flap closure were assessed. Repeated measure ANOVA was done for intragroup comparison at different time intervals. Independent student t-test was done for intergroup comparison. Results: Wound healing was better in the test group in the early stages and postoperative pain and the time required for the flap closure were significantly less in the cyanoacrylate group. Conclusion: N-Butyl cyanoacrylate is a reliable alternative to conventional sutures as it is easy to apply, shortens the operation time, causes a less inflammatory response, and reduces postoperative pain while facilitating primary closure similar to conventional silk sutures. Clinical significance: N-Butyl cyanoacrylate a newer tissue adhesive is painless, biocompatible, better tissue handling, less time-consuming, and better acceptability by the patient for the closure of flaps than silk sutures.


PDF Share
  1. Takei HH, Carranza FA, Jonathan H. Do: the periodontal flap Newman T, Klokkevold C, ed. Textbook of Carranza's clinical periodontology. 12th ed., Elsevier; 2015. pp. 582–586.
  2. Miller GM, Dannenbaum R, Cohen DW. A preliminary histologic study of the wound healing of mucogingival flaps when secured with the cyanoacrylate tissue adhesives. J Periodontol 1974;45(8):608–618. DOI: 10.1902/jop.1974.45.8.2.608.
  3. Habib A, Mehanna A, Medra A. Cyanoacrylate: a handy tissue glue in maxillofacial surgery: our experience in Alexandria, Egypt. J Maxillofac Oral Surg 2013;12(3):243–247. DOI: 10.1007/s12663-012-0433-z.
  4. Coover HW Jr, Toyner FP, Shearer NH Jr, et al. Chemistry and performance of cyanoacrylate tissue adhesives. Soc Plastic Engineers J 1959;15:413.
  5. Binnie WH, Forrest JO. A study of tissue response to cyanoacrylate adhesive in periodontal surgery. J Periodontol 1974;45(8):619–625. DOI: 10.1902/jop.1974.45.8.2.619.
  6. DeRenzis FA, Aleo JJ. An in vitro bioassay of cyanoacrylate cytotoxicity. Oral Surg, Oral Med, Oral Pathol 1970;30(6):803–808. DOI: 10.1016/0030-4220(70)90344-0.
  7. Forrest JO. The use of cyanoacrylates in periodontal surgery. J Periodontol 1974;45(4):225–229. DOI: 10.1902/jop.1974.45.4.225.
  8. Bhaskar SN, Frisch J. Use of cyanoacrylate adhesives in dentistry. J Am Dent Assoc 1968;77(4):831–837. DOI: 10.14219/jada.archive.1968.0310.
  9. Salata LA, Mariguela VC, Antunes AA, et al. Short-term evaluation of grafsfxed with either N-butyl-2-cyanocrylate or screws. J Oral Maxillofac Surg 2014;72(4):676–682. DOI: 10.1016/j.joms.2013.11.016.
  10. Rezende MLRD, Cunha PDO, Damante CA, et al. Cyanoacrylate adhesive as an alternative tool for membrane fixation in guided tissue regeneration. J Contemp Dent Pract 2015;16(6):512–518. DOI: 10.5005/jp-journals-10024-1714.
  11. Tavelli L, Asa'ad F, Acunzo R, et al. Minimizing patient morbidity following palatal gingival harvesting: a randomized controlled clinical study. Int J Periodont Restorat Dentis 2018;38(6):e127–e134. DOI: 10.11607/prd.3581.
  12. Ozcan M, Ucak O, Alkaya B, et al. Efects of platelet-rich fbrin on palatal wound healing after free gingival graft harvesting: a comparative randomized controlled clinical trial. Int J Periodont Restorat Dentis 2017;37(5):270–278. DOI: 10.11607/prd.3226.
  13. Soni R, Narula A, Kumar M, et al. Comparing cyanoacrylate tissue adhesive and conventional subcuticular skin sutures for maxillofacial incisions—a prospective randomized trial considering closure time, wound morbidity, and cosmetic outcome. J Oral Maxillofac Surg 2013;71(12):2152.e1–2152.e8. DOI: 10.1016/j.joms.2013.08.029.
  14. Perez M, Fernandez I, Marquez D, et al. Use of N-butyl-2-cyanoacrylate in oral surgery: biological and clinicalevaluation. Artific Organs 2000;24(3):241–243. DOI: 10.1046/j.1525-1594.2000.06519.x.
  15. Nevins M, Mendoza-Azpur G, Angelis ND, et al. The biocompatibility of cyanoacrylate tissue adhesive inconjunction with a collagen membrane for providing soft andhard tissue regeneration in extraction socket preservation procedures. Int J Periodont Restorat Dentis 2018;38:s37–s42. DOI: 10.11607/prd.3770.
  16. Gumus P, Buduneli E. Graft stabilization with cyanoacrylatedecreases shrinkage of free gingival grafts. Australian Dent J 2014;59(1):57–64. DOI: 10.1111/adj.12149.
  17. Kulkarni S, Dodwad V, Chava V. Healing of periodontal flaps when closed with silk sutures and N-butyl cyanoacrylate: a clinical and histological study. Indian J Dent Res 2007;18(2):72–77. DOI: 10.4103/0970-9290.32424.
  18. Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of victamine C. J Periodontol 1970;41(1):41–43. DOI: 10.1902/jop.1970.41.41.41.
  19. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21(6):533–551. DOI: 10.3109/00016356309011240.
  20. Huang LH, Neiva RE, Wang HL. Factors affecting the outcomes of coronally advanced flap root coverage procedure. J Periodontol 2005;76(10):1729–1734. DOI: 10.1902/jop.2005.76.10.1729.
  21. Kulkarni SS, Chava VK. Comparison of cyanoacrylate and silk sutures on healing of oral wounds--an animal model study. Indian J Dent Res 2003;14(4):254–258.
  22. Giray CB, Atasever A, Durgun B, et al. Clinical and electron microscope comparison of silk sutures and n-butyl-2-cyanoacrylate in human mucosa. Aust Dent J 1997;42(4):255–258. DOI: 10.1111/j.1834-7819.1997.tb00130.x.
  23. Borie E, Rosas E, Kuramochi G, et al. Oral applications of cyanoacrylate adhesives: a literature review. Bio Med Res Int 2019. 1–5.
  24. Leggat PA, Smith DR, Kedjarune U. Surgical applications of cyanoacrylate adhesives: a review of toxicity. ANZ J Surg 2007;77(4):209–213. DOI: 10.1111/j.1445-2197.2007.04020.x.
  25. Petrie ME. Cyanoacrylate adhesives in surgical applications. Rev Adhes Adhesi 2014;2(3):253–310. DOI: 10.7569/RAA.2014.097306.
  26. Macht SD, Krizek TJ. Sutures and suturing-current concepts. J Oral Surg 1978;36(9):710–712.
  27. Giray CB, Sungur A, Atasever A, et al. Comparison of silk sutures and n-butyl-2-cyanoacrylate on the healing of skin wounds. A pilot study. Aust Dent J 1995;40(1):43–45. DOI: 10.1111/j.1834-7819.1995.tb05613.x.
  28. Greer Jr RO. Studies concerning the hsitotoxicity of isobutyl-2-cyanoacrylate tissue adhesive when employed as an oral hemostat. Oral Surg Oral Med Oral Pathol 1975;40(5):659–669. DOI: 10.1016/0030-4220(75)90376-x.
  29. Khurana JV, Mali AM, Mali RS, et al. Comparative evaluation of healing after periodontal flap surgery using isoamyl 2-cyanoacrylate (bioadhesive material) and silk sutures: a split-mouth clinical study. J Indian Soc Periodon 2016;20(4):417–422. DOI: 10.4103/0972-124X.194267.
  30. Mahajani A, Menaka KB, Jagirdar SAA, et al. Evaluation of antibacterial efficacy and healing with cyanoacrylate tissue adhesive after periodontal flap surgery. Clin Dentis 2019;XIII:12–17. DOI: 10.33882/ClinicalDent.13.24801.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.