Aim and objective: This study evaluated the color difference (ΔE*), translucency, and color assimilation (CA) of monoshade resin composites (MCs) with other shaded resin composites (SCs) using disks and teeth-like resin composite models. Materials and methods: Total 72 disks, 60 anterior, and 60 posterior models were prepared using MC and each SC (VITA shades B1, A1, B2, A2, and A3; n = 12 per shade). The ΔE* and translucency parameter were determined from disks using a spectrophotometer. Tooth preparation was performed in teeth-like models made of SC and filled with MC. Recording of visual score (VS) was performed by eight viewers for shade matching of MC with SC disks and teeth-like models. The VS values were designated numerically between score 1 and 5 and CA was calculated for disks and models. Results: The mean ΔE* value for disks was least for shade B1 (6.4 ± 2.2) and showed significant increase toward darker shade A3 (19.7 ± 3.3). The MC was highly translucent than that of all SC (p < 0.01; Tukeys post hoc). Mean VS values of models showed small to acceptable difference in all shades within the range of 3–5. Mean CA values of models increased from lighter to darker shades along with increase in ΔE* (Pearson's r = 0.8) of disks. Conclusion: The MC exhibited color difference with all tested shades to various extents; however, it demonstrated relatively high translucency and admissible CA with different shades. Clinical significance: Monoshade resin composites with appreciable color matching compensate for shade mismatch and replace multiple shaded composites in the inventory.