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VOLUME 10 , ISSUE 4 ( July-August, 2019 ) > List of Articles

REVIEW ARTICLE

Tasty Herb that Heals: A Review of Cosmos caudatus (Ulam Raja) and its Potential Uses in Dentistry

Usman H Uzbek, Wan NS Shahidan

Keywords : Cosmos caudatus, Pharmacological use, Traditional medicine, Ulam raja

Citation Information : Uzbek UH, Shahidan WN. Tasty Herb that Heals: A Review of Cosmos caudatus (Ulam Raja) and its Potential Uses in Dentistry. World J Dent 2019; 10 (4):321-324.

DOI: 10.5005/jp-journals-10015-1651

License: CC BY-NC 4.0

Published Online: 00-08-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: In recent years, there has been an increase in research on herbal derivatives with regards to their medicinal use. This review aims to summarize the scientific reports on one such herb, Cosmos caudatus. Our primary focus is to highlight its pharmacological properties and their potential applications in the field of dentistry. Background: The vascular plant biodiversity of Southeast Asia is second to that of South America, with many of these plants being used for their traditional medicinal benefits. One such herb that is popular in Malaysia is C. caudatus, locally referred to as ulam raja. It is an edible herb, commonly served in the form of a salad and is also used in traditional medicine practices to boost blood circulation, increase strength of bones, reduce fever, treat infections, and improve skin texture. Recent scientific studies have reported numerous pharmacological benefits of C. caudatus ranging from being an antioxidant agent to having bone-protective properties. These properties are attributed to a rich source of biochemical compounds found in the herb. A PubMed and Science Direct database search was conducted revealing 25 papers relevant to our review of C. caudatus, describing its traditional uses, pharmacological uses, botanical description, and phytochemical description. Review results: Published studies have reported that C. caudatus has potent antioxidant properties. It has shown both antibacterial and antifungal activities. Extracts of C. caudatus are capable of acting as an antihypertensive and antidiabetic agent, in both human and animal models. It also plays a role as a bone-protective and bone-proliferative agent. Conclusion: C. caudatus has the potential of being greatly beneficial in treating various dental diseases due to its pharmacological properties. Clinical significance: There is need for further research into this abundant natural resource in order to explore its potential uses in clinical dentistry.


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  1. Reihani S, Azhar M. Antioxidant activity and total phenolic content in extracts of selected traditional Malay salads (Ulam). Int Food Res J 2012;19(4):1439–1444.
  2. Umberto Q. CRC world dictionary of medicinal and poisonous plants; 2012.
  3. Bodeker G, Salleh H, Shekar S. Health and beauty from the rainforest: Malaysian traditions of ramuan. Biotropics Ramuan; 2009.
  4. Burkill IH. A dictionary of the economic products of the Malay Peninsula. 2nd ed., 1966.
  5. Rasdi NH, Samah OA, Sule A, et al. Antimicrobial studies of Cosmos caudatus kunth.(compositae). J Med Plant Res 2010;4(8):669–673.
  6. Moshawih S, Cheema M, Ahmad Z, et al. A comprehensive review on Cosmos caudatus (Ulam raja): pharmacology, ethnopharmacology, and phytochemistry. Int Res J Edu Sci 2017;1(1):14–31.
  7. Mediani A, Abas F, Khatib A, et al. 1H-NMR-based metabolomics approach to understanding the drying effects on the phytochemicals in Cosmos caudatus. Food Res Int 2012;49(2):763–770. DOI: 10.1016/j.foodres.2012.09.022.
  8. Lee TK, Vairappan CS. Antioxidant, antibacterial and cytotoxic activities of essential oils and ethanol extracts of selected South East Asian herbs. J Med Plants Res 2011;5(21):5284–5290.
  9. Shui G, Leong LP, Wong SP. Rapid screening and characterisation of antioxidants of Cosmos caudatus using liquid chromatography coupled with mass spectrometry. J Chromatogr B 2005;827(1): 127–138. DOI: 10.1016/j.jchromb.2005.07.029.
  10. Mustafa RA, Hamid AA, Mohamed S, et al. Total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants. J Food Sci 2010;75(1):28–35. DOI: 10.1111/j.1750-3841.2009.01401.x.
  11. Leong LP, Shui G. An investigation of antioxidant capacity of fruits in Singapore markets. Food Chem 2002;76(1):69–75. DOI: 10.1016/S0308-8146(01)00251-5.
  12. Aksakalli S. Antioxidants in dentistry: Review of literature. Dentistry 2013;4(1):1–3. DOI: 10.4172/2161-1122.1000181.
  13. Carnelio S, Khan SA, Rodrigues G. Definite, probable or dubious: antioxidants trilogy in clinical dentistry. Br Dent J 2008;204(1):29–32. DOI: 10.1038/bdj.2007.1186.
  14. Patel S, Hans MK, Chander S, et al. Antioxidants in endodontics: A strategic review. J Clin Diagn Res 2015;9(5):12–17. DOI: 10.7860/JCDR/2015/12903.5944.
  15. King M, Chatelain K, Farris D, et al. Oral squamous cell carcinoma proliferative phenotype is modulated by proanthocyanidins: a potential prevention and treatment alternative for oral cancer. BMC Complement Altern Med 2007;7(1):22–27. DOI: 10.1186/1472-6882-7-22.
  16. Emmanuel R, Palanisamy S, Chen SM. Antimicrobial efficacy of green synthesized drug blended silver nanoparticles against dental caries and periodontal disease causing microorganisms. Mater Sci Eng C 2015;5(6):374–379. DOI: 10.1016/j.msec.2015.06.033.
  17. Saeed S, Hasan S, Parmar SS. Conventional and Recent Diagnostic Aids in oral Candidal Infections: A Brief overview. Biomed Pharmacol J 2017;10(1):419–426. DOI: 10.13005/bpj/1124.
  18. McCullough MJ, Savage NW. Oral candidosis and the therapeutic use of antifungal agents in dentistry. Aust Dent J 2005;50:S36–S39. DOI: 10.1111/j.1834-7819.2005.tb00383.x.
  19. Vikneswari P, Hamid AA, Amin I, et al. Effect of Cosmos caudatus Kunth leaves on the lipid profile of a hyperlipidemia-induced animal model. J Food Chem Nutr 2014;2(1):43–51.
  20. Loh SP, Hadira O. In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. Malays J Nutr 2011;17(1):77–86.
  21. Cheng SH, Ismail A, Anthony J, et al. Eight weeks of Cosmos caudatus (ulam raja) supplementation improves glycemic status in patients with type 2 diabetes: a randomized controlled trial. Evid Based Complement Alternat Med 2015;2015:405615. DOI: 10.1155/2015/405615.
  22. Mark AM. Diabetes and oral health. J Am Dent Assoc 2016;147(10):852. DOI: 10.1016/j.adaj.2016.07.010.
  23. Amalia L, Anggadiredja K, Sukrasno FI, et al. Antihypertensive potency of wild Cosmos (Cosmos caudatus Kunth, Asteraceae) leaf extract. J Pharmacol Toxicol 2012;7(8):359–368. DOI: 10.3923/jpt.2012.359.368.
  24. Southerland JH, Gill DG, Gangula PR, et al. Dental management in patients with hypertension: challenges and solutions. Clin Cosmet Investig Dent 2016;8:111–120. DOI: 10.2147/CCIDE.S99446.
  25. Mohamed N, Gwee Sian Khee S, Shuid AN, et al. The effects of Cosmos caudatus on structural bone histomorphometry in ovariectomized rats. Evid Based Complement Alternat Med 2012;2012:817814. DOI: 10.1155/2012/817814.
  26. Mohamed N, Sahhugi Z, Ramli ES, et al. The effects of Cosmos caudatus (ulam raja) on dynamic and cellular bone histomorphometry in ovariectomized rats. BMC Res Notes 2013;6(1):239.
  27. Mulligan R, Sobel S. Osteoporosis: diagnostic testing, interpretation, and correlations with oral health—implications for dentistry. Dent Clin 2005;49(2):463–484. DOI: 10.1016/j.cden.2004.10.005.
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