World Journal of Dentistry

Register      Login

VOLUME 10 , ISSUE 5 ( September-October, 2019 ) > List of Articles

REVIEW ARTICLE

Pharmacovigilance: The Least Understood and Least Practiced Science in Dentistry

Chaya Chhabra, Kumar G Chhabra, Akanksha Goyal, Gururaghavendran Rajesh, Almas Binnal

Keywords : Dental professionals, Indian scenario, Pharmacovigilance

Citation Information : Chhabra C, Chhabra KG, Goyal A, Rajesh G, Binnal A. Pharmacovigilance: The Least Understood and Least Practiced Science in Dentistry. World J Dent 2019; 10 (5):402-406.

DOI: 10.5005/jp-journals-10015-1661

License: CC BY-NC 4.0

Published Online: 01-10-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Aim: The purpose of this review was to explore the overall scenario of pharmacovigilance, its aims, challenges, and recommendations pertaining to dentistry for further improvements. Materials and methods: Literature search was done with the help of the Endnote software, followed by vigilantly arranging the material in a coordinated way. Results: Adverse drug reactions (ADRs) are among the top 10 leading causes of all-cause mortality. In order to reduce the harm to the patients and serve the public health mission, there is a definite need for developing mechanisms for evaluating and monitoring the safety of medicines in India. Therefore, the requirement for developing a well-organized pharmacovigilance system is imperative. Different countries have developed their own reporting guidelines for pharmacovigilance. The reporting guidelines are conceived to adapt to the specific requirements of any country and the prime focus of these adverse event reporting systems is improving the patient\'s health and safety. The Central Drugs Standard Control Organization (CDSCO) has initiated a nation-wide pharmacovigilance program in India. It aims to protect the health of the patients by assuring drug safety under the aegis of Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India. In dentistry, the science of pharmacovigilance is rarely applied and its practice among dental health professionals, including reporting of ADRs, is minimal. However, studies have shown that the dental professionals comprehend the importance of pharmacovigilance and its application in dentistry. Conclusion: It is essential to foster a sense of trust among patients regarding the medicines they use, to ensure that risks in drug use are anticipated and managed. This will eventually enhance the confidence of patients on the healthcare delivery system in general. Clinical significance: The practice of dentistry involves prescribing various medications for patient use. It is therefore the duty of the dentist to comprehend and identify the adverse effects of the drugs. Dentists should also know about the right channel for reporting any instances of ADRs. They should also strive toward increasing the awareness among patients regarding possible side effects so that any untoward consequences can be avoided. This will be an invaluable aid in furthering the public health mission of improving the health of the populations.


PDF Share
  1. Fonkwo PN. Pricing infectious disease: the economic and health implications of infectious diseases. EMBO Rep 2008;9(Suppl 1):S13–S17. DOI: 10.1038/embor.2008.110.
  2. Brahma DK, Wahlang JB, Marak MD, et al. Adverse drug reactions in the elderly. J Pharmacol Pharmacother 2013;4(2):91–94. DOI: 10.4103/0976-500X.110872.
  3. WHO Policy Perspectives on Medicines—Pharmacovigilance: ensuring the safe use of medicines. World Health Organization, Geneva; 2004.
  4. Agarwal PK An Insight to Pharmacovigilance: A Global Perspective, 1st ed., Mitosis International; 2013. pp. 1–3.
  5. Kalaiselvan V, Thota P, Singh GN. Pharmacovigilance programme of India: recent developments and future perspectives. Indian J Pharmacol 2016;48(6):624–628. DOI: 10.4103/0253-7613.194855.
  6. Suke SG, Kosta P, Negi H. Role of pharmacovigilance in India: an overview. Online J Public Health Inform 2015;7(2):e223. DOI: 10.5210/ojphi.v7i2.5595.
  7. Kalaiselvan V, Srivastava S, Singh A, et al. Pharmacovigilance in India: present scenario and future challenges. Drug Saf 2019;42(3):339–346. DOI: 10.1007/s40264-018-0730-7.
  8. National Pharmacovigilance Program [Internet]. 2019 [cited 2019 Mar 15]. Available from: https://www.aiims.edu/en/national-introduction.html?id=166.
  9. Bavdekar SB, Karande S. National pharmacovigilance program. Indian Pediatr 2006;43(1):27–32.
  10. Smith RG, Burtner AP. Oral side-effects of the most frequently prescribed drugs. Spec Care Dentist 1994;14(3):96–102. DOI: 10.1111/j.1754-4505.1994.tb01112.x.
  11. Hema N, Bhuvana K. Pharmacovigilance: the extent of awareness among the final year students, interns and postgraduates in a government teaching hospital. J Clin Diagn Res 2012;6:1248–1253.
  12. Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother 2008;42(7):1017–1025. DOI: 10.1345/aph.1L037.
  13. Janaje MTM, Singer DR. Costs and prevention of adverse drug reactions. Eur J Intern Med 2001;12(5):403–405. DOI: 10.1016/S0953-6205(01)00156-X.
  14. Wu WK, Pantaleo N. Evaluation of outpatient adverse drug reactions leading to hospitalization. Am J Health Syst Pharm 2003;60(3):253–259. DOI: 10.1093/ajhp/60.3.253.
  15. Feely J, Moriarty S, O’Connor P. Stimulating reporting of adverse drug reactions by using a fee. BMJ 1990;300(6716):22–23. DOI: 10.1136/bmj.300.6716.22.
  16. Patil A, Gurav YA, Thorat MB, et al. Survey of pharmacovigilance awareness among healthcare professionals. Int J Pharmacol Ther 2014;4:31–34.
  17. Gupta SK, Nayak RP, Shivaranjani R, et al. A questionnaire study on the knowledge, attitude, and the practice of pharmacovigilance among the healthcare professionals in a teaching hospital in South India. Perspect Clin Res 2015;6(1):45–52. DOI: 10.4103/2229-3485.148816.
  18. Desai CK, Iyer G, Panchal J, et al. An evaluation of knowledge, attitude, and practice of adverse drug reaction reporting among prescribers at a tertiary care hospital. Perspect Clin Res 2011;2(4):129–136. DOI: 10.4103/2229-3485.86883.
  19. Gupta P, Udupa A. Adverse drug reaction reporting and pharmacovigilance: knowledge, attitudes and perceptions amongst resident doctors. J Pharm Sci Res 2011;3:1064–1069.
  20. Khan SA, Goyal C, Chandel N, et al. Knowledge, attitudes, and practice of doctors to adverse drug reaction reporting in a teaching hospital in India: an observational study. J Nat Sci Biol Med 2013;4(1):191–196. DOI: 10.4103/0976-9668.107289.
  21. Muraraiah S, Rajarathna K, Sreedhar D, et al. A questionnaire study to assess the knowledge, attitude and practice of pharmacovigilance in a paediatric tertiary care centre. J Chem Pharm Res 2011;3:416–422.
  22. Remesh A. Identifying the reasons for under reporting of ADR: a cross sectional survey. Res J Pharm Biol Chem Scia 2012;3:1379–1386.
  23. Iffat W, Shakeel S, Naseem S, et al. Attitudinal survey to assess medical and dental students’ belief of ADR reporting in Pakistan. Int J Pharm Pharm Sci 2014;6(5):279–283.
  24. Talattof Z, Azad A. An evaluation of knowledge, attitude and practice of adverse drug reaction reporting in dental practice. Pak J Nutr 2015;14(10):712–715. DOI: 10.3923/pjn.2015.712.715.
  25. Praveen S, Prakash JR, Manjunath GN, et al. Adverse drug reaction reporting among medical and dental practitioners: a KAP study. Indian J Med Spec 2013;4(1):10–15.
  26. Shalini S, Mohan S. Knowledge and attitude towards pharmacovigilance and adverse drug reaction reporting among dental students in a private university, Malaysia. J Young Pharm 2015;7(2):118–125. DOI: 10.5530/jyp.2015.2.10.
  27. Bansode AA, Zad VR, Sawant SD, et al. Awareness about pharmacovigilance among resident doctors in a tertiary care hospital. J Evol Med Dent Sci 2015;4(2):207–210. DOI: 10.14260/jemds/2015/33.
  28. Arjun TN, Sudhir H, Gouraha A, et al. Assessment of knowledge, attitude and practice related to pharmacovigilance among the healthcare professionals in a teaching hospital in central India: an questionnaire study. World J Pharm Sci 2015;4(4):785–799.
  29. Pimpalkhute SA, Jaiswal KM, Sontakke SD, et al. Evaluation of awareness about pharmacovigilance and adverse drug reaction monitoring in resident doctors of a tertiary care teaching hospital. Indian J Med Sci 2012;66(3–4):55–61. DOI: 10.4103/0019-5359.110902.
  30. Khan SA, Goyal C, Tonpay SD. A study of knowledge, attitudes, and practice of dental doctors about adverse drug reaction reporting in a teaching hospital in India. Perspect Clin Res 2015;6(3):144–149. DOI: 10.4103/2229-3485.159938.
  31. Sudhakar S, Madhavan A, Balasubramani S. Attitude of dentists toward pharmacovigilance and reporting adverse drug reactions: a cross-sectional study. J Adv Clin Res Insights 2015;2:242–247. DOI: 10.15713/ins.jcri.87.
  32. Ghosh R, Bhatia MS, Bhattacharya SK. Pharmacovigilance: master key to drug safety monitoring and its status in India. Delhi Psychiatry J 2012;15(1):412–415.
  33. Chhabra KG, Sharma A, Chhabra C, et al. knowledge, attitude, and practices regarding pharmacovigilance and adverse drug reaction reporting among dental students in a teaching hospital, Jodhpur, India: a cross-sectional Study. J Contemp Dent Pract 2017;18(10):964–969. DOI: 10.5005/jp-journals-10024-2157.
  34. Kumar M, Deolia S, Totade S, et al. Knowledge, attitude and practices of pharmacovigilance among healthcare professionals in a medical and dental institute: a comparative study. Int J Curr Res 2017;9(7):55139–55144.
  35. Bhagavathula AS, Elnour AA, Jamshed SQ, et al. Health professionals’ knowledge, attitudes and practices about pharmacovigilance in India: a systematic review and meta-analysis. PLoS One 2016;11(3):e0152221. DOI: 10.1371/journal.pone.0152221.
  36. Laporte JR. Fifty years of pharmacovigilance-medicines safety and public health. Pharmacoepidemiol Drug Saf 2016;25(6):725–732. DOI: 10.1002/pds.3967.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.