The most common method for the removal of all-ceramic restorations is to use a highspeed handpiece with a stone or bur. Unfortunately, this process can be difficult, time-consuming and may lead to the loss of healthy tooth structures. Lasers have been suggested and used to remove ceramic orthodontic brackets, laminate veneers and full anatomical crowns. Aim: Aim of the present study was to evaluate the debonding effect of erbium, chromium-doped yttrium, scandium, gallium and garnet (ErCr:YSGG) on Computer-aided design and computer-aided manufacturing (CAD/CAM) end crown restorations. Materials and methods: Overall, 30 molar samples were prepared for this study and divided into two groups as follows:   Group A–(n = 15): Endocrowns subjected to ErCr:YSGG laser application.   Group B–(n = 15): Endocrowns not subjected to the laser (control). Endocrowns were fabricated from lithium disilicate ceramics and manufactured using a CAD/CAM machine. Cementation was done using Bisco Duo Link Universal^™ resin cement. ErCr:YSGG laser was used with wavelength 2780 nm, 0.3J energy, 10 Hz frequency and 1000 μm tip size. Pull out test was done using a universal testing machine. Results: It was found that Non-laser group recorded statistically significant (p < 0.05) higher mean value (258.14 ± 63.43 N) for debonding than Laser group mean value (156.66 ± 32.89 N) as indicated by student t-test. Additionally, no carbonization at the dentin/cement interface was observed. Conclusion: According to the results of this study, ErCr: YSGG application can be considered a conservative method for the debonding of all ceramic endocrowns. Clinical significance: Some practitioners have been against the use of endocrown restorations due to the difficulty faced in removal and retrieval, the use of laser is an alternative, effective and conservative method.