Aim: Aim of the study was to evaluate the efficacy of manual toothbrush (STIM^® 42 Orthodontic toothbrush) with or without an interdental brush (IDB) (STIM^® PROXA-Extra fine) on gingival status in patients undergoing fixed orthodontic therapy. Materials and methods: In a randomized control trial of 60 subjects undergoing orthodontic therapy with Begg's appliance enrolled for the study. They were placed in a maintenance regimen with (STIM^® 42 orthodontic toothbrush) after thorough scaling and root planning (SRP) for four weeks before the commencement of the study. This was done to attain uniformity and avoid bias in both the groups at the baseline. At the end of four weeks, subjects were randomly divided into two groups, group I–30 subjects used STIM^® 42 Orthodontic toothbrush only and group II–30 subjects used STIM^® PROXA-extra fine as an adjunct to STIM^® 42 Orthodontic toothbrush for four weeks. Clinical parameters such as bonded bracket plaque index (BBPI), gingival index (GI), and gingival bleeding index (GBI) were recorded at baseline, 1, 2 and 4 weeks. Analysis of data was done using repeated measures analysis of variance (ANOVA) and unpaired student t-test using Statistical Package for the Social Sciences (SPSS) 22 software. Results: Result of the study showed a statistically significant reduction (p < 0.001) in BBPI, GI and GBI in group. II subjects when compared to group. I. Conclusion: Manual orthodontic brush along with IDB proved to be superior, in controlling plaque, gingival inflammation and gingival bleeding in subjects undergoing fixed orthodontic treatment. Clinical significance: Our study supports the use of interdental brushes along with manual toothbrush during fixed orthodontic treatment. It can significantly improve plaque control, thereby improving gingival health. To promote gingival health dentists need to motivate and reinforce this beneficial practice among their patients undergoing fixed orthodontic treatment.