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VOLUME 10 , ISSUE 3 ( May-June, 2019 ) > List of Articles

REVIEW ARTICLE

Implications of Plasma Lymphoblastic Cells in Lymphoreticular Disorders: An Overview

Marin Abraham

Keywords : Hematopoietic stem cells, Immunoglobulins, Lymphoreticular system, Lymphoblasts, Plasmablasts

Citation Information : Abraham M. Implications of Plasma Lymphoblastic Cells in Lymphoreticular Disorders: An Overview. World J Dent 2019; 10 (3):241-245.

DOI: 10.5005/jp-journals-10015-1636

License: CC BY-NC 4.0

Published Online: 01-06-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Aim: The aim of this review was to emphasize the diverse morphologic features of plasma lymphoblastic cells in lymphoreticular disorders to arrive at a precise diagnosis. Background: The lymphoreticular system comprises of a group of cells with a common lineage and primary function of immunoregulation. Specific immunity is achieved by the combined effects of macrophages and lymphocytes, and, therefore, it is the lymphoreticular system. These cells are scattered in different parts of the body and share some functional characteristics. At both functional and anatomical levels, lymphoreticular tissue can be categorized into primary and secondary lymphoid organs that predominantly produce lymphocytes and plasma cells. Review results: The plasma lymphoblastic lesions/malignancies comprise of characteristic cells like buttock cells, cells with irregular nuclei, cells with cleaved nuclear outlines, etc. Identification of such cells amidst sheets of malignant lymphoblastic cells is challenging. However, sound knowledge about the morphology of these cells and their immunohistochemical panel of markers may provide a clue for diagnosis. Conclusion: The predominant cell types noted in plasma lymphoblastic lesions histopathologically are immature lymphocytes and plasma cells in their varied cell activity suggest the biologic behavior of the lesion. Clinical significance: Understanding and identifying the normal and pathological cellular and nuclear morphology of the lymphoreticular cells can aid in the definitive diagnosis of the plasma lymphoblastic disorders and predict its biological nature.


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