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VOLUME 9 , ISSUE 6 ( November-December, 2018 ) > List of Articles
Fereshteh A Kalate, Leila Gholami, Ebrahim Alijani, Morad Hedayatipanah, Saharnaz Kosari
Keywords : Chronic periodontitis,,Gingival crevicular fluid,Interleukin-17
Citation Information : Kalate FA, Gholami L, Alijani E, Hedayatipanah M, Kosari S. Level of Interleukin-17 in Gingival Crevicular Fluid of Patients with Chronic Periodontitis. World J Dent 2018; 9 (6):495-499.
License: CC BY-NC 4.0
Published Online: 01-12-2018
Copyright Statement: Copyright © 2018; The Author(s).
Aim: Interleukin-17 (IL-17) is a proinflammatory cytokine that plays an important role in inflammation and tissue destruction in periodontal disease. This study aimed to assess the level of IL-17 in gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) and healthy controls.
Materials and methods: This case-control study was performed on 30 patients with CP (53% males, 47% females, mean age of 37.2 ± 5.95 years) and 30 healthy controls (53% males, 47% females, mean age of 30.63 ± 5.22 years). The GCF was collected using paper points. A paper point was inserted into the pocket and remained there for 30 seconds. It was then placed in a sterile tube containing 300 μL of phosphate buffered saline and stored at -70° C. Level of IL-17 was measured using enzyme-linked immune sorbent assay (ELISA). The level of IL-17 was compared between the two groups using independent sample t-test at 0.05 level of significance.
Results: The mean GCF level of IL-17 was 53.46 pg/L in CP patients and 38.1 pg/L in healthy controls. This difference was statistically significant (p = 0.025).
Conclusion: The CP patients had significantly higher GCF level of IL-17 compared to healthy controls.
Clinical significance: The finding of this study highlight the role of IL-17 in the pathogenesis of periodontal disease. Within the limitations of the present study, it may be suggested that measurement of GCF level of IL-17 can serve as a bioindicator of periodontal destruction and gingival inflammation.
Keywords: Chronic periodontitis, Gingival crevicular fluid, Interleukin-17.
How to cite this article: Kalate FA, Gholami L, Alijani E, Hedayatipanah M, Kosari S. Level of Interleukin-17 in Gingival Crevicular Fluid of Patients with Chronic Periodontitis . World J Dent 2018;9(6):495-499.
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