VOLUME 9 , ISSUE 1 ( January-February, 2018 ) > List of Articles
Marin Abraham, Parimala Sagar
Citation Information : Abraham M, Sagar P. Diagnostic Panel of Markers CD45, CD20, CD3, CD138, and CD56 for Oral Solitary Plasmacytoma of Bone. World J Dent 2018; 9 (1):53-58.
DOI: 10.5005/jp-journals-10015-1507
License: CC BY 3.0
Published Online: 01-12-2017
Copyright Statement: Copyright © 2018; The Author(s).
The present case aims to emphasize on the role of immunophenotyping in plasmacytic malignancies. Solitary plasmacytoma of bone (SPB) is a rare entity often encountered in vertebrae and less frequently in long bones. Its presence in jaws is extremely rare, accounting for 4.4% of cases only. About 5% of patients with plasma cell dyscrasias present with SPB. An elderly male patient reported with a chief complaint of growth in the anterior region of the lower jaw since 3 months. The histopathological features following an incisional biopsy were suggestive of pyogenic granuloma. Serological investigations revealed seropositivity for human immunodeficiency virus (HIV)-1 antibody with hypergammaglobulinemia and hypoalbuminemia. Histopathology of excisional biopsied tissue revealed a round cell malignancy with plasmacytic morphology. Further, to arrive at a specific final diagnosis, immunohistochemistry (IHC) was employed with a panel of markers CD45, CD20, CD3, CD138, and CD56. This panel enabled us to establish a final diagnosis of SPB with clinicopathologic correlation. The present case posed a diagnostic dilemma as it presented with overlapping features of non-Hodgkin's lymphoma (NHL), multiple myeloma (MM), extramedullary plasmacytoma (EMP), and plasmablastic lymphoma (PBL). A thorough clinical, radiological, serological, and IHC panel helped to diagnose the present case. The CD56 enabled differentiation between SPB and PBL. Thereby, this article emphasizes on the need for a panel of IHC markers that permit definitive diagnosis of lymphopoietic malignancies. Timely diagnosis of malignant lesions is an essential concern for effective management. Thus, we emphasize that the IHC is a valuable investigative tool in the diagnosis of round cell tumors with plasmacytoid morphology. Abraham M, Augustine D, Sagar P, Rao RS, Prasad K, Sowmya SV, Haragannavar VC, Nambiar S. Diagnostic Panel of Markers CD45, CD20, CD3, CD138, and CD56 for Oral Solitary Plasmacytoma of Bone. World J Dent 2018;9(1):53-58.