World Journal of Dentistry

Register      Login

VOLUME 8 , ISSUE 4 ( July-August, 2017 ) > List of Articles

RESEARCH ARTICLE

Quantity Differences of Secondary Metabolites (Saponins, Tannins, and Flavonoids) from Binahong Plant Extract (Anredera cordifolia (Ten.) Steenis) treated and untreated with Colchicines that play a Role in Wound Healing

Olivia A Hanafiah, Diana S Hanafiah, Eva S Bayu, Syafrudin Ilyas, Marline Nainggolan, Endang Syamsudin

Citation Information : Hanafiah OA, Hanafiah DS, Bayu ES, Ilyas S, Nainggolan M, Syamsudin E. Quantity Differences of Secondary Metabolites (Saponins, Tannins, and Flavonoids) from Binahong Plant Extract (Anredera cordifolia (Ten.) Steenis) treated and untreated with Colchicines that play a Role in Wound Healing. World J Dent 2017; 8 (4):296-299.

DOI: 10.5005/jp-journals-10015-1453

Published Online: 01-08-2017

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Aim

The aim of this study is to compare whether there are differences in the value content of secondary metabolites (saponins, tannins, and flavonoids) between the group treated with Binahong leaves (administration of colchicines) and the group treated with Binahong leaves without the application of colchicines.

Materials and methods

The design of this study is an experimental research laboratory study. This research was done in four different places in which colchicines were applied to improve the quality of Binahong, conducted in the USU Agricultural Faculty's Greenhouse, whereas no application of colchicines was done in the Desa Simpang Pergendangan Kelurahan Tiga Binanga Kabupaten Karo harvesting Binahong plant. The pharmacy faculty of USU was chosen as a place to obtain the extract and the Laboratory of the Research Institute for Spices and Medicinal Plants (Balitro) was where the phytochemical analysis was conducted.

Results

The results showed that there were differences in the descriptive values of secondary metabolites in the Binahong leaf extract, such as saponins, tannins, and flavonoids, wherein the group with colchicines was higher than groups without colchicines, but there was no statistical differences between the groups treated with colchicines and those not treated with colchicines (value p > 0.05).

Conclusion

Administration of colchicines can improve the content of secondary metabolites in Binahong leaf extract and the plant morphology without affecting the content of the plant extract.

Clinical significance

Secondary metabolites in herbal plants, such as saponins, flavonoids, and tannins are able to speed up the healing process. One of the plants that have all three of these active compounds is Binahong (Anredera cordifolia). Binahong leaf extract can stimulate the process of fibroblasts and collagen formation that will accelerate the process of wound healing. Colchicine as a reagent for the mutation is able to affect the number of leaves and morphological characteristics of the Binahong plant.

How to cite this article

Hanafiah OA, Hanafiah DS, Bayu ES, Abidin T, Ilyas S, Nainggolan M, Syamsudin E. Quantity Differences of Secondary Metabolites (Saponins, Tannins, and Flavonoids) from Binahong Plant Extract (Anredera Cordifolia (Ten.) Steenis) treated and untreated with Colchicines that play a Role in Wound Healing. World J Dent 2017;8(4):296-299.


PDF Share
  1. Determination of saponin compound from Anredera Cordifolia (Ten) stennis plant (binahong) to potential treatment for several diseases. J Agric Sci 2011 Dec;3(4):224-232.
  2. Effect of topical application of binahong (Anredera cordifolia (Ten.) steenis leaf paste in wound healing process in mice. Althea Med J 2014 Jun;1(1):6-11.
  3. The effect of formula to physical properties of wound healing gel of ethanolic extract of binahong (Anredera cordifolia (Ten.) steenis). Int J Pharm Sci Res 2012 Nov;3(11):4254-4259.
  4. The effect of colchicine on morphology and number of chromosome of binahong plant [Anredera cordifolia (Ten.) Steenis]. Proceeding of the International Symposium on Agricultural and Biosystem Engineering. Indonesia: Departemen Teknik Pertanian Fakultas Teknologi Pertanian Universitas Gadjah Mada; 2016. p. 1-5.
  5. Penggandaan kromosom dan pertumbuhan somaklonal andalas (Morus macroura Miq. Var Macroura) yang diperlakukan dengan kolkhisin. J Bio Unand 2012 Sep;1(1):23-26.
  6. Factors affecting wound healing. J Dent Res 2010 Mar;89(3):219-229.
  7. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001 Oct;74(4):418-425.
  8. Antimicrobial, antioxidant, and wound healing properties of Kigelia africana (Lam.) Beneth. and Strophanthus hispidus DC. Adv Pharmacol Sci 2013 Mar; 2013:692613.
  9. Pharmacological properties of flavonoids including flavonolignans-integration of petrocrops with drug development from plants. J Sci Ind Res 2006 Jun;65(6):477-484.
  10. Test efektivitas salep ekstrak daun binahong (Anredera cordifolia (Ten.) Steenis) pada kelinci (Oryctolagus cuniculus) yang terinfeksi bakteri Staphylococcus aureus. Pharmacon J Ilmiah Farm 2013 Feb;2(1);8-9.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.