World Journal of Dentistry

Register      Login

VOLUME 8 , ISSUE 3 ( May-June, 2017 ) > List of Articles

RESEARCH ARTICLE

Synergistic Effects of Growth Factor, Bone Graft, and Resorbable Barrier Membrane in Management of Dehiscence and Fenestration of Dental Implants

Umesh P Verma

Citation Information : Verma UP. Synergistic Effects of Growth Factor, Bone Graft, and Resorbable Barrier Membrane in Management of Dehiscence and Fenestration of Dental Implants. World J Dent 2017; 8 (3):177-182.

DOI: 10.5005/jp-journals-10015-1434

Published Online: 01-06-2017

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Aim

The present study was primarily designed to evaluate the outcome of guided bone graft regeneration in peri-implant defects by combining recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and granules of beta-tricalcium phosphate (B-TCP) mounted by resorbable biomesh membrane. Secondary objective was to determine the value of resorbable barrier membrane to improve the efficacy of the growth factormediated regeneration.

Materials and methods

A randomized controlled study comprised 14 participants (8 males and 6 females, mean age 37 years, range 19—55 years), in which a total of 15 implants (10 in maxilla and 5 in the mandible) were placed. Fifteen implant sites were randomly divided by picking a code into three groups: Test group I (n = 5) ß-TCP + rhPDGF (0.3 mg/mL) + biomesh, test group II (n = 5) ß-TCP + rhPDGF, and control (n = 5) ß-TCP + biomesh. The experimental site was examined clinically for the gingival status and radiographically for the bone status.

Results

Statistically significant difference in preoperative and postoperative measurements was observed for test groups I and II in all the parameters except width; in contrast, there was no significant difference observed for the control group from baseline to 5 months postoperatively. On intergroup comparison, statistically significant difference was observed between test group I vs control group and test group II vs control group, but it was not significant between test groups I and II, which was further confirmed using global performance scale score.

Conclusion

It concluded that rhPDGF-BB and ß-TCP mounted by resorbable biomesh membrane played a synergistic role in the management of peri-implant defects.

Clinical significance

Bone regenerated using ß-TCP with rhPDGF-BB in the reversal of peri-implant defects.

How to cite this article

Arora R, Verma UP, Dixit J, Lal N. Synergistic Effects of Growth Factor, Bone Graft, and Resorbable Barrier Membrane in Management of Dehiscence and Fenestration of Dental Implants. World J Dent 2017;8(3):177-182.


PDF Share
  1. Peri-implant bone tissue strains in cases of dehiscence: a finite element study. Clin Oral Implants Res 2002 Jun;13(3):327-333.
  2. Guided tissue regeneration for implants placed into extraction sockets: a study in dogs. J Periodontol 1991 Nov;62(11):703-709.
  3. The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. J Periodontol 1991 Jul;62(7):458-467.
  4. Growth factors in periodontal regeneration. Compend (Suppl) 1994;(18):S672-S677.
  5. Effect of rhPDGF-BB on bone turnover during periodontal repair. J Clin Periodontol 2006 Feb;33(2):135-140.
  6. Initial pattern of angiogenesis and bone formation following lateral ridge augmentation using rhPDGF and guided bone regeneration: an immunohistochemical study in dogs. Clin Oral Implants Res 2010 Jan;21(1):90-99.
  7. Effect of absorbable membranes on sandwich bone augmentation. Clin Oral Implants Res 2008 Jan;19(1):32-41.
  8. Restoration of osseous defects in maxillofacial casualities. J Am Dent Assoc 1969 Apr;78(4):767-776.
  9. Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 1988 May;81(5):672-676.
  10. Bone augmentation at fenestrated implants by an osteopromotive membrane technique. A controlled clinical study. Clin Oral Implants Res 1991 Oct-Dec;2(4):159-165.
  11. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol 2005 Dec;76(12):2205-2215.
  12. rhPDGF-BB promotes healing of periodontal defects: 24-month clinical and radiographic observations. Int J Periodontics Restorative Dent 2006 Jun;26(3):223-231.
  13. Alveolar ridge augmentation with Bio-Oss: a histologic study in humans. Int J Periodontics Restorative Dent 2001 Jun;21(3):288-295.
  14. Long-term results of implants treated with guided bone regeneration: a 5-year prospective study. Int J Oral Maxillofac Implants 2001 May-Jun;16(3):355-366.
  15. Bone augmentation by means of barrier membranes. Periodontol 2000 2003;33:36-53.
  16. Bone regeneration around titanium dental implants in dehisced defect sites: a clinical study. Int J Oral Maxillofac Implants 1992 Summer;7(2):233-245.
  17. Healing of implant dehiscence defects with and without expanded polytetrafluoroethylene membranes: a controlled clinical and histological study. Clin Oral Implants Res 1994 Jun;5(2):98-104.
  18. Immediate transmucosal implants using the principle of guided tissue regeneration (II). A cross-sectional study comparing the clinical outcome 1 year after immediate to standard implant placement. Clin Oral Implants Res 1996 Sep;7(3):268-276.
  19. Comparison of bioabsorbable and bioinert membranes for guided bone regeneration around non-submerged implants. An experimental study in the mongrel dog. Clin Oral Implants Res 1999 Jun;10(3):226-237.
  20. The effect of a deproteinized bovine bone mineral on bone regeneration around titanium dental implants. Clin Oral Implants Res 1998 Jun;9(3):151-162.
  21. Evaluation of a new bioresorbable barrier to facilitate guided bone regeneration around exposed implant threads. An experimental study in the monkey. Int J Oral Maxillofac Surg 1998 Aug;27(4):315-320.
  22. Bone tissue reaction around implants placed in a compromised jaw. J Clin Periodontol 1999 Oct;26(10):629-635.
  23. Bone healing around implants placed in a jaw defect augmented with Bio-Oss. An experimental study in dogs. J Clin Periodontol 2000 Nov;27(11):799-805.
  24. Vertical ridge augmentation with the use of recombinant human platelet-derived growth factor-BB and bovine bone mineral: a case report. Int J Periodontics Restorative Dent 2009 Jun;29(3):289-295.
  25. Sandwich bone augmentation using recombinant human platelet-derived growth factor and betatricalcium phosphate alloplast: case report. Int J Periodontics Restorative Dent 2008 Feb;28(1):83-87.
  26. The effects of recombinant human growth/differentiation factor-5 (rhGDF-5) on bone regeneration around titanium dental implants in barrier membrane-protected defects: a pilot study in the mandible of beagle dogs. Int J Oral Maxillofac Implants 2009 Jan-Feb;24(1):31-37.
  27. Comparative analysis of collagen membranes for the treatment of implant dehiscence defects. Clin Oral Implants Res 2003 Feb;14(1):80-90.
  28. Treatment of dehiscences and fenestrations around dental implants using resorbable and nonresorbable membranes associated with bone autografts: a comparative clinical study. Int J oral Maxillfac implants 1997 Mar;12(2):159-167.
  29. Immunolocalization of platelet-derived growth factor A and B chains and PDGF-alpha and beta receptors in human gingival wounds. J Periodontal Res 1997 Feb;32(2):209-214.
  30. Platelet-derived growth factor in chemotactic for fibroblasts. J Cell Biol 1982 Feb;92(2):584-588.
  31. Bone regeneration in extraction sites after immediate placement of an e-PTFE membrane with or without a biomaterial. A report on 12 consecutive cases. Clin Oral Implants Res 1996 Sep;7(3):277-285.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.