World Journal of Dentistry

Register      Login

VOLUME 7 , ISSUE 1 ( January-March, 2016 ) > List of Articles


Concept of Synthetic Lethality in Cancer

Citation Information : Concept of Synthetic Lethality in Cancer. World J Dent 2016; 7 (1):0-0.

DOI: 10.5005/wjoud-7-1-v

License: CC BY-SA 4.0

Published Online: 01-03-2016

Copyright Statement:  Copyright © 2016; The Author(s).


PDF Share
  1. Exploration of synthetic lethal interactions as cancer drug targets. Future Oncol 2010 Nov;6(11):1789-1802.
  2. Synthetic lethality: general principles, utility and detection using genetic screens in human cells. FEBS Lett 2011 Jan 3;585(1):1-6.
  3. A lethal combination for cancer cells: synthetic lethality screenings for drug discovery. Eur J Cancer 2010 Nov;46(16):2889-2895.
  4. Integrating genetic approaches into the discovery of anticancer drugs. Science 1997 Nov 7;278(5340):1064-1068.
  5. Synthetic lethal vulnerabilities of cancer. Annu Rev Pharmacol Toxicol 2015;55:513-531.
  6. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005 Apr 14;434(7035):917-921.
  7. Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer. Front Biosci (Landmark Ed) 2009 Jan 1;14:2904-2910.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.