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VOLUME 4 , ISSUE 1 ( January-March, 2013 ) > List of Articles


Effect of Nonsurgical Periodontal Therapy on Some Oxidative Stress Markers in Patients with Chronic Periodontitis: A Biochemical Study

Tabita Benjamin, Abdul S Aziz, Madhav G Kalekar, Adinath N Suryakar, Milsee M Prakashan, Mohammed Nadeem A Bijle

Citation Information : Benjamin T, Aziz AS, Kalekar MG, Suryakar AN, Prakashan MM, Bijle MN. Effect of Nonsurgical Periodontal Therapy on Some Oxidative Stress Markers in Patients with Chronic Periodontitis: A Biochemical Study. World J Dent 2013; 4 (1):17-23.

DOI: 10.5005/jp-journals-10015-1196

Published Online: 01-03-2013

Copyright Statement:  Copyright © 2013; The Author(s).



Chronic periodontitis is the inflammatory disease of the periodontium; the tissue that surround and support the teeth. The aim of the study was to estimate and compare some biochemical oxidative stress markers in patients with chronic periodontitis and healthy controls and to assess the effect of nonsurgical periodontal therapy on these parameters.

Materials and methods

Eighty-two chronic periodontitis patients and 120 healthy controls were recruited for the study. The periodontal status was evaluated using gingival index (GI), plaque index (PI), papillary bleeding index (PBI) and clinical attachment loss (CAL). The biochemical parameters estimated were total antioxidant capacity (TAOC), antioxidant enzymes RBC-superoxide dismutase (RBC-SOD) and glutathione peroxidase (GPx), vitamin C, malondialdehyde (MDA) and Creactive protein (CRP) were also evaluated. Nonsurgical periodontal therapy (scaling and root planing; SRP) was performed on chronic periodontitis patients and a follow-up was done after 3 months.


The study suggests that oxidative stress is induced in chronic periodontitis, as the levels of CRP, MDA and RBC-SOD were significantly higher (p < 0.001) and those of TAOC, GPx and vitamin C were significantly lower (p < 0.001) compared to healthy controls at baseline. SRP therapy significantly improved the clinical and biochemical oxidative stress markers in periodontitis patients.


Chronic periodontitis patients show higher inflammatory manifestations and oxidative stress. SRP therapy helps in lowering inflammatory burden and improving systemic oxidant: Antioxidant imbalance. The SRP therapy may be a useful support in the control and prevention of various inflammatory diseases associated with periodontitis.

How to cite this article

Aziz AS, Kalekar MG, Benjamin T, Suryakar AN, Prakashan MM, Bijle MNA. Effect of Nonsurgical Periodontal Therapy on Some Oxidative Stress Markers in Patients with Chronic Periodontitis: A Biochemical Study. World J Dent 2013;4(1):17-23.

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