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VOLUME 3 , ISSUE 4 ( October-December, 2012 ) > List of Articles

RESEARCH ARTICLE

A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus

Rubina Anjum, Jasmin Singh, Shailesh Kudva

Citation Information : Anjum R, Singh J, Kudva S. A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus. World J Dent 2012; 3 (4):330-334.

DOI: 10.5005/jp-journals-10015-1184

Published Online: 01-12-2012

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

Probable mechanism of pigmentation in oral lichen planus which is associated with anxiety disorder and its relation to gamma aminobutyric acid whose imbalance in brain occurs during stress and strain.

Materials and methods

A cross-sectional study comprising of 33 cases of clinically diagnosed oral lichen planus was conducted. Ethical clearance and informed consent was obtained. Detailed history was recorded and clinical examination was conducted. All patients were subjected to thorough routine blood, urine and stool examination for any systemic conditions. Clinical photographs and biopsies were obtained. The biopsy specimens were subjected to hematoxylin and eosin and periodic acid Schiff's reagent staining.

Results

Histopathological features of lichen planus include hyperkeratosis, liquefaction degeneration of stratum basale and subepithelial band of chronic inflammatory cells. Lichen planus is related to anxiety as predisposing factor.

Conclusion

Due to excitation of melanocytes lichen planus are seen with pigmentation.

How to cite this article

Anjum R, Singh J, Kudva S. A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus. World J Dent 2012;3(4):330-334.


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  1. On lichen planus. J Cut Med Dis Skin 1896;3:117-32.
  2. Oral lichen planus. The clinical, historical and therapeutic features of 100 cases. Oral Surg Oral Med Oral Pathol 1990;70:165-71.
  3. Scully C, Lichen planus: A review and update on pathogenesis. J Oral Pathol 1985;141:431-58.
  4. Serum immunoglobulins and antibodies in patients with oral lichen planus. Int J Oral Surg 1983;12:274
  5. Lichen planus: A theory of pathogenesis. Oral Surg Oral Med Oral Pathol 1983;56:521
  6. Lichen planus. J Cutan Dis 1919;37:639-70.
  7. Lichen plan buccal. Revue de Stomatologic 1971;72:214
  8. Dematology (2nd ed). WB Saunders, Philadelphia 1985:1741-43.
  9. Oral lichen planus I: A clinical evaluation of 115 cases. Oral Surg Oral Med Oral Pathol 1968;25:31-42.
  10. Diseases of the skin (5th ed). London; J&A Churchill, 1911; Large 8 vo, p 782.
  11. Treatment of oral lichen planus with betamethasone. Br Med J 1986;1:86-89.
  12. A histological evaluation of melanosis in oral epithelial dysplasia. Ind J Oral Pathol 1994;1:20-23.
  13. Lichen planus in an infant less than 6 months old. Arch Derm Syph 1929;19:671
  14. Oral manifestation of 50 cases of lichen planus. Br Dent J 1954;96:1
  15. Shklar G, The oral lesions of lichen planus, observation of a 100 cases. Oral Surg Oral Med Oral Pathol 1961;14:164
  16. Lichen planus: Statistical study of 41 cases. Arch Dermatol 1985;71:515-19.
  17. Follow-up studies in oral lichen planus. Int J Surg 1973;2:13-19.
  18. Oral lichen planus. Br J Oral Surg 1974;11:187-206.
  19. A textbook of oral pathology (5th ed). Philadelphia: WB Saunders 1993:1103-07.
  20. A clinical study of lichen planus. Arch Derm Syp 1920;1:43-49.
  21. Lichen planus: A critical analysis of 64 cases. J Cutan Dis 1919;37:671
  22. Natural history of oral lichen planus. Int J Derm Veneral 1974;40:204-07.
  23. Oral lichen planus: A review. Int J Oral Surg 1987;16:172-78.
  24. Oral lichen planus: The evidence regarding potential malignant transformation. J Oral Pathol 1978;7:1-7.
  25. Oral squamous cell carcinoma arising in a patient with long standing lichen planus a case report. Oral Surg Oral Med Oral Pathol 1990;70:282-85.
  26. Malignant potential of oral lichen planus: Observations from 722 patients from India. J Oral Pathol 1986;15:71-77.
  27. The controversy of premalignant potential of oral lichen planus is over. Oral Surg Oral Med Oral Pathol 1992;73:704-06.
  28. Histochemical studies on lichen planus. Oral Surg Oral Med Oral Pathol 1974;37:239-48.
  29. Study on oral lichen planus. III. Clinical and histologic correlation in 230 patients. Oral Surg Oral Med Oral Pathol 1975;39:122
  30. Oral lichen planus II: A histological evaluation of 97 cases. Oral Surg Oral Med Oral Pathol 1968;25:31-42.
  31. Shklar G, Histopathology and histochemistry of dermatologic lesions in the mouth. Oral Surg Oral Med Oral Pathol 1961;14:1069-84.
  32. El-Labban NG, Civatte bodies and the actively dividing epithelial cells in oral lichen planus. Br J Derm 1974;90:365
  33. The behavior of basement membrane of skin and oral lesions in patient with lichen planus, pemphigus, lupus erythematous. Oral Surg Oral Med Oral Pathol 1996;22:752
  34. Electron microscopic studies of oral lichen planus. G Ital Derm 1966;107:765-88.
  35. Lichenoid dysplasia: A distinct histopathological entity. Oral Surg Oral Med Oral Pathol 1985;30:308-15.
  36. Oral lichen planus associated with pigmentation. J Oral M 1979;34:23-24.
  37. Psychological factors associated with oral lichen planus. J Oral Pathol 1995;24:273
  38. Pigmented peripheral nerve sheath tumor or oral cavity with expression of AP-2 beta and C-RET. Oral Surg Oral Med Oral Pathol 1997;84:40-44.
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