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VOLUME 2 , ISSUE 4 ( October-December, 2011 ) > List of Articles


Immunofluorescence in Oral Pathology: Part I—Methodology

BR Premalatha, Roopa S Rao, Vijaya Mysorekar

Citation Information : Premalatha B, Rao RS, Mysorekar V. Immunofluorescence in Oral Pathology: Part I—Methodology. World J Dent 2011; 2 (4):326-331.

DOI: 10.5005/jp-journals-10015-1107

Published Online: 01-12-2011

Copyright Statement:  Copyright © 2011; The Author(s).


Immunofluorescence is an immunological method used to demonstrate the presence of antigen and antibodies in tissues or serum. Immunofluorescence techniques have become indispensable in modern pathology laboratories and have greatly contributed to the diagnosis, treatment and understanding of autoimmune bullous diseases, hereditary bullous diseases, collagen-vascular diseases, many inflammatory dermatosis and cutaneous tumors. This review emphasizes the basics of immunofluorescence techniques, methodology, interpretation of the results and the newer advancements in the field.

The application of immunofluorescence techniques in various vesiculobullous disorders will be extensively discussed in the subsequent parts. Part II will deal with the pemphigus group and other dermatological conditions with oral involvement and part III with subepidermal immunobullous diseases.

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