World Journal of Dentistry

Register      Login

VOLUME 2 , ISSUE 3 ( July-September, 2011 ) > List of Articles

REVIEW ARTICLE

Therapeutic Management of Oral Lichen Planus: A Review for the Clinicians

Raghavendra Kini, DV Nagaratna, Ankit Saha

Citation Information : Kini R, Nagaratna D, Saha A. Therapeutic Management of Oral Lichen Planus: A Review for the Clinicians. World J Dent 2011; 2 (3):249-253.

DOI: 10.5005/jp-journals-10015-1091

Published Online: 00-09-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Lichen planus is a chronic, noninfectious, inflammatory disease of skin and mucous membrane. Intraorally the buccal mucosa, tongue and gingiva are the sites commonly involved. It affects women more often than men in a ratio 3:2. It has well-recognized clinical signs and symptoms, the symptoms may range from none, through mild discomfort to severe burning sensation. In comparison with cutaneous form, the oral lesions are more resistant to therapy and are less likely to undergo spontaneous remission.

Treatment is administered mainly to resolve symptoms and discomfort. Choice of treatment may vary from patient to patient depending on the severity of the lesion and systemic condition of the patient. A variety of agents have been employed to treat oral lichen planus, but corticosteroid remains the mainstay of treatment. However, in the recent past, newer drugs like Tacrolimus have shown promising results. In view of fact that there is a risk of malignant transformation of atrophic and erosive forms of oral lichen planus, the patients need to be actively treated and kept on long-term follow-up. This article highlights various agents used in treatment of oral lichen planus, their mechanism of action, dosage and untoward effects.


PDF Share
  1. Oral lichen planus. J Cutan Med Dis Skin 1869:117-32.
  2. A prospective study of findings and management in 214 patients with oral lichen planus. Oral Surg Oral Med Oral Pathol 1991;72:665-70.
  3. Oral lichen planus. Oral Surg Oral Med Oral Pathol 1968;25:31-41.
  4. Oral lichen planus. J Oral Maxillofac Pathol 2005;9(1):3-5.
  5. Immunopathology of oral mucosal ulcerative, desquamative, and bullous diseases: Selective review of literature. Oral Surg Oral Med Oral Pathol 1994;77:555-71.
  6. Oral lichenoid drug eruptions their recognition and management. Dent Update 2002;29:442-47.
  7. Treatment of oral lichen planus with topical vitamin A acid. J Oral Pathol 1985;39:186-90.
  8. Effect of topical cyclosporin rinse on oral lichen planus—a double blind study. N Engl J Med 1990;323:290-94.
  9. Prednisone and azathioprine in the treatment of patients with vesiculobullous erosive oral disease. Oral Surg Oral Med Oral Pathol 1981;52:257-63.
  10. An open clinical trial of a new mouth—PUVA variant in the treatment of oral lichenoid lesions. Oral Surg Oral Med Oral Pathol 1997;84: 502-05.
  11. Oral lichen planus: A review. Br J Oral Maxillofac Surg 2000;38:370-77.
  12. Systemic and topical corticosteroids treatment of oral lichen planus. J Oral Pathol Med 2003;32(6):323-29.
  13. Efficacy of topical retinoic acid compared with topical flucinolone acetonide in the treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol 1994;83:21-25.
  14. Double-blind clinical trial of 0.05% clobetsol proprionate ointment in orabase and 0.05% flucinonide ointment in orobase in the treatment of patients with oral vesiculo erosive diseases. Oral Surg Oral Med Oral Pathol 1994;77:598-604.
  15. Betamethosone valerate aerosol in the treatment of oral lichen planus. Br J Dermatol 1997;96: 652-59.
  16. Steroids in treatment of lichen planus: A review. J Oral Sci 2008;50(4):377-85.
  17. Cyclosporin A in an adhesive base for treatment of recalcitrant oral lichen planus. Oral Surg Oral Med Oral Pathol 1994;78:437-41.
  18. Dramatic response to levimisole and low dose prednisolone in 23 patients with oral lichen planus. Oral Surg Oral Med Oral Pathol 1995;80:705-09.
  19. Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus. J Clin Periodontol 2008;35:244-49.
  20. Current controversies in oral lichen planus: Report of an international consensus meeting. (Part 2). Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:164-78.
  21. Successful treatment of oral erosive lichen planus with mycophenolate mofetil. J Eur Acad Dermatol Venereol 2007;21(2):259-60.
  22. Treatment of erosive oral lichen planus with thalidomide (French). Ann Dermatol Venereol 2003;130:1109-12.
  23. Treatment of oral lichen planus with photodynamic therapy mediated methylene blue: A case report. Med Oral Patol Oral Cir Bucal 2006;11:E126-29.
  24. Management of oral lichen planus. Arch Iranian Med 2005;8(4):252-56.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.