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VOLUME 2 , ISSUE 2 ( April-June, 2011 ) > List of Articles

REVIEW ARTICLE

Rabbits as Animal Models in Contemporary Implant Biomaterial Research

Himanshu Arora, Anil Nafria, Anup Kanase

Citation Information : Arora H, Nafria A, Kanase A. Rabbits as Animal Models in Contemporary Implant Biomaterial Research. World J Dent 2011; 2 (2):129-134.

DOI: 10.5005/jp-journals-10015-1069

Published Online: 00-06-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Development of an optimal interface between bone and orthopedic or dental implants has taken place for many years. In order to determine whether a newly developed implant material conforms to the requirements of biocompatibility, mechanical stability and safety, it must undergo rigorous testing both in vitro and in vivo. Results from in vitro studies can be difficult to extrapolate to the in vivo situation. For this reason the use of animal models is often an essential step in the testing of orthopedic and dental implants prior to clinical use in humans. This review discusses the reasons, the importance, and the research carried out in rabbits in our quest to develop a dental implant ideally suited for human bone.


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  1. Three-dimensional reconstruction of confocal laser microscopy images to study the behaviour of osteoblastic cells grown on biomaterials. Biomaterials Jan 2002;23(2):397-406.
  2. Spine update: The use of animal models to study spinal fusion. Spine (Phila Pa 1976) 1 Sep 1994;19(17):1998-2006.
  3. Use of animal models in musculoskeletal research. Iowa Orthop J 1998;18:118-23.
  4. Effect of sex steroids on peak bone density of growing rabbits. Am J Physiol Oct 1988;255(4 Pt 1):E416-21.
  5. Biological evaluation of medical devices. 1994(Pt 6):1-11.
  6. An interspecies comparison of bone fracture properties. Biomed Mater Eng 1998;8(1):1-9.
  7. Changes of femoral bone tissue microstructure in transgenic rabbits. Folia Biol (Praha) 2005;51(5):140-44.
  8. Collagen fibre arrangement in the tibial plateau articular cartilage of man and other mammalian species. J Anat Jul 1998;193(Pt 1):23-34.
  9. Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits. Skeletal Radiol Jan 2006;35(1): 34-41.
  10. Osseointegrated titanium implants. Acta Orthop Scand 1981;52:155-70.
  11. Proliferation and differentiation parameters of human osteoblasts on titanium and steel surfaces. J Biomed Mater Res Feb 2001;54(2):209-15.
  12. Histological response to ivory implanted in rabbit mandibles. J Dent Res 1975;54:561-66.
  13. The effect of plastic implants on jaws and adjacent tissues of the rabbit. J Prosth Dent 1968;19: 514-22.
  14. The biocompatibility of dental implant materials measured in an animal model. J Dent Res 1981;60:44-49.
  15. On the nature of the biocompatibility and on medical applications of NiTi shape memory and superelastic alloys. Bio-Med Mater Eng 1996;6:267-89.
  16. Porous TiNi biomaterial by self-propagating high-temperature synthesis. Adv Eng Mater 2004;6:403-06.
  17. Preliminary histomorphometric comparisons of two implant biomaterials in a rabbit model. Dental Materials 2010;26(2):e152.
  18. A removal torque and histomorphometric study of commercially pure niobium and titanium implants in rabbit bone. Clin Oral Impl Res 1991;2: 24-29.
  19. Histomorphologic evaluation of Ti-13Nb-13Zr alloys processed via powder metallurgy. A study in rabbits. Materials Science and Engineering C 2008;28:223-27.
  20. Bone growth around silicon nitride implants—An evaluation by scanning electron microscopy. Material Characterization 2008;59:1339-41.
  21. Bone attachment to glass-fibre-reinforced composite implant with porous surface. Acta Biomaterialia 2009;5:1639-46.
  22. Histological findings of bone remodeling around smooth dental titanium implants inserted in rabbit's tibias. Ann Anat 2002;184:359-62.
  23. Design of dental implants, influence on the osteogenesis and fixation. J Mater Sci: Mater Med 2008;19:2851-57
  24. Influence of implant taper on the primary and secondary stability of osseointegrated titanium implants. Clin Oral Implants Res Aug 2004;15(4): 474-80.
  25. Stimulation of directed bone growth at oxidized titanium implants by macroscopic grooves: An in vivo study. Clin Implant Dent Relat Res 2005;7 Suppl 1:S76-82.
  26. Effects of implant thread geometry on percentage of osseointegration and resistance to reverse torque in the tibia of rabbits. J Periodontol Sep 2004;75(9):1233-41.
  27. Evaluation of an endosseous titanium implant with a sandblasted and acid-etched surface in the canine mandible: Radiographic results. Clin Oral Implants Res 1996;7:240-52.
  28. Optimization of surface micromorphology for enhanced osteoblast responses in vitro. Int J Oral Maxillofac Implants 1992;7:302-10.
  29. Effect of titanium surface roughness on chondrocyte proliferation, matrix production, and differentiation depends on the state of cell maturation. J Biomed Mater Res 1996;30: 145–55.
  30. Anchorage of TiO2-blasted, HA-coated and machined implants: An experimental study with rabbits. J Biomed Mater Res 1995;29:1223-31.
  31. Experimental study of turned and grit-blasted screw-shaped implants with special emphasis on effects of blasting material and surface topography. Biomaterials 1996;17:15-22.
  32. Torque and histomorphometric evaluation of c.p. titanium screws blasted with 25- and 75-μm-sized particles of Al2O3. J Biomed Mater Res 1996;30:251-60.
  33. Titanium release from implants prepared with different surface roughness: An in vitro and in vivo study. Clin Oral Impl Res 15: 2004;505-12.
  34. Early endosseous integration enhanced by dual acid etching of titanium: A torque removal study in the rabbit. Clin Oral Impl Res 2001;12:350-57.
  35. Removal torque and histomorphometric investigation of 4 different titanium surfaces: An experimental study in the rabbit tibia. Int J Oral Maxillofac Implants 2000;15:668-74.
  36. The removal torque of titanium screw inserted in rabbit tibia treated by dual acid etching. Biomaterials Sep 2003;24(20):3611-17.
  37. Osseointegration enhanced by chemical etching of the titanium surface: A torque removal study in the rabbit. Clin Oral Implants Res Dec 1997;8(6):442-47.
  38. The relation between surface roughness and interfacial shear strength for bone-anchored implants. A mathematical model. J Biomech 1999;32:829-36.
  39. Interface shear strength of titanium implants with a sandblasted and acid-etched surface: A biomechanical study in the maxilla of miniature pigs. J Biomed Mater Res 1999;45: 75-83.
  40. Bone response to surface-modified titanium implants: Studies on the early tissue response to machined and electropolished implants with different oxide thicknesses. Biomaterials Mar 1996;17(6):605-16.
  41. Mechanical and histologic examination of titanium alloy material treated by sandblasting and anodic oxidization. Int J Oral Maxillofac Implants 2005;20:48-53.
  42. Qualitative and quantitative observations of bone tissue reactions to anodised implants. Biomaterials Apr 2002;23(8):1809-17.
  43. Relationship between surface properties (roughness, wettability and morphology) of titanium and dental implant removal torque. J Mech Behav Biomed Mater Jul 2008;1(3):234-42.
  44. Trabecular bone response to surface roughened and calcium phosphate (Ca-P) coated titanium implants. Biomaterials Feb 2002;23(4):1025-31.
  45. Histological findings in titanium implants coated with calcium phosphate ceramics installed in rabbit's tibias. Ann Anat Mar 2005;187(1):93-98.
  46. Biological responses to hydroxy apatite surfaces deposited via a coincident microblasting technique. Biomaterials Jan 2010;31(3):515-22.
  47. Anchorage of titanium implants with different surface characteristics: An experimental study in rabbits. Clin Implant Dent Relat Res 2000;2(3): 120-28.
  48. An in vivo study of bone response to implants topographically modified by laser micromachining. Biomaterials Feb 2003;24(5):701-10.
  49. A removal torque of the laser-treated titanium implants in rabbit tibia. Biomaterials Nov 2003;24(26):4859-63.
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