World Journal of Dentistry

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VOLUME 2 , ISSUE 1 ( January-March, 2011 ) > List of Articles


Langerhans Cell Histiocytosis

S Jayachandran, N Balaji

Citation Information : Jayachandran S, Balaji N. Langerhans Cell Histiocytosis. World J Dent 2011; 2 (1):57-62.

DOI: 10.5005/jp-journals-10015-1055

Published Online: 00-03-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Langerhans cell histiocytosis (LCH) is rare unique disorder of the reticuloendothelial system characterized by an abnormal proliferation of histiocytes and eosinophilic leukocytes. Lichtenstein gave the term Histiocytosis X in 1953 to include three clinical varieties; Eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease, which shared some common histologic features and clinical findings. In 1973, the term LCH was introduced as an alternative to histiocytosis X. LCH may manifest orally with single or multiple lesions of the alveolar or basal bone, ulcerated mucosal lesions accompanied by adenopathies and/or periodontal lesions, presenting gingival inflammation, bleeding, recession, necrosis, mobility of teeth and premature loss of teeth. Herewith, we report a case of LCH in a 45-year-old male with a characteristic oral and radiological findings. The purpose of this case report is to highlight the unique and rare presentation of oral and multiple skeletal involvement of Langerhans cell histiocytosis.

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