Comparative Analysis of Efficacy of Activated Platelet-rich Plasma along with Demineralized Freeze-dried Bone Allograft in Periodontal Intrabony Defects: A Pilot Study
Citation Information :
Kaur M, Bhardwaj A, Sharma S. Comparative Analysis of Efficacy of Activated Platelet-rich Plasma along with Demineralized Freeze-dried Bone Allograft in Periodontal Intrabony Defects: A Pilot Study. World J Dent 2024; 15 (9):762-766.
Aim: The present study aims to demonstrate the regenerative potential of a novel combination of activated platelet-rich plasma (PRP) and demineralized freeze-dried bone allograft (DFDBA) in the treatment of periodontal intrabony defects.
Materials and methods: A total of 30 subjects were allocated into two groups. Group A (test group) received a combination of activated PRP and DFDBA and was compared with the conventional approach of using traditional PRP (i.e., without an activating agent) with DFDBA in group B (control group).
Result: Both groups showed a remarkable gain in linear and percentage bone fill and a marked reduction in probing pocket depth (PPD) and relative attachment level (RAL); however, the results with activated PRP and DFDBA were comparably superior to those with inactivated PRP and DFDBA.
Conclusion: The combination of DFDBA and activated PRP improves both clinical and radiographic periodontal parameters in the surgical management of periodontal intrabony defects.
Clinical significance: This combination therapy presents a promising avenue for enhancing periodontal tissue regeneration and merits further exploration in clinical practice as a means to optimize periodontal treatment outcomes.
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