Aim: The aim of the study was to compare the potency of titanium-prepared platelet-rich fibrin (T-PRF) gel combined with demineralized freeze-dried bone allograft (dFDBA) for socket preservation vs spontaneous healing using cone beam computed tomography (CBCT). Materials and methods: Twenty-six systemically healthy patients were selected from the outpatient pool of the Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai. Both male and female patients above 18 years of age, having a hopeless tooth requiring extraction, were selected for this study. These subjects were randomly allocated into two groups, with 13 subjects in each group. Extraction was performed, and CBCT images for both groups were obtained at baseline immediately following extraction. In group A, extraction sockets were left to heal spontaneously without any graft material and without sutures. In group B, extraction sockets were grafted using a combination of T-PRF gel with dFDBA, covered with a T-PRF membrane and Healiguide™, followed by the placement of horizontal mattress sutures. Patients were recalled, and CBCT images were taken at the 180th-day follow-up. Results: Crestal bone width was maintained in group B, showing a statistically significant difference, whereas a slight decrease was observed in group A at the 180th-day follow-up. Crestal bone height decreased in group A, but there was an increase in crestal bone height in group B, which was statistically significant at the 180th day. Conclusion: It can be concluded that socket preservation using T-PRF gel with dFDBA, covered with a T-PRF membrane and Healiguide™, showed a better outcome in terms of bone width and height after extraction, making it a promising biomaterial for regeneration. Clinical significance: Socket preservation is an effective method for bone regeneration following extraction. The use of biomaterials such as allograft and T-PRF further enhances bone formation with osteoinductive properties.