Aim: The color stability of orthodontic wires exposed to dietary media varies. To investigate this, we measured and compared the color stability of Teflon-coated Ni–Ti (nickel–titanium) orthodontic esthetic archwires after immersion in turmeric, coffee, tea, and cola staining solutions. Materials and methods: The sample consisted of 32 epoxy and Teflon-coated nickel–titanium archwires measuring 0.019 × 0.025 inches each. Each sample was created by connecting 10-mm-long wire segments and joining their juxtaposed ends with ethyl cyanoacrylate. Four different staining solutions were used, including coffee, tea, cola, and turmeric solutions. After numbering each subgroup, the specimens were immersed in the solution and stored in distilled water at 37°C for 24 hours. The initial measurement was taken after removing them from the distilled water. Following the initial measurement (T0), the samples were placed in a container containing the prepared staining solutions. The color measurements were repeated after 7 days (T1), 14 days (T2), and 21 days (T3) of immersion in the solution. The spectrophotometer was calibrated prior to taking the measurements, as per the manufacturer's instructions. The color was measured using a computerized spectrophotometer based on the Commission Internationale de l'Eclairage system L*, a*, and b*, as well as color variations (ΔE). Results: Among the Teflon-coated esthetic archwires (group I), turmeric had the highest ΔE (41.22) value from baseline reading to 21 days, which was statistically significant with p ≤ 0.000 when compared to coffee, tea, and cola. Turmeric had the highest ΔE (6.35) compared to other staining solutions, followed by tea, coffee, and cola. Conclusion: In the current study, epoxy resin-coated archwires were more color-stable than Teflon-coated wires. Clinically, these color changes are associated with the foods and beverages consumed. Clinical significance: Color stability of esthetic archwires used in orthodontic treatment is critical, and any discoloration, staining, or changes in the patient's appearance will impact their willingness to cooperate and accept treatment.