Aims and background: This study aims to compare the effectiveness of oak gall oil with Triphala oil as an adjuvant to tobacco cessation counseling (TCC) in the reversal of oral leukoplakia. Materials and methods: Patients prediagnosed with oral leukoplakia (n = 30) were randomized (1:1 ratio) to receive topical application of either oak gall oil (n = 15) or Triphala oil (n = 15) for 3 months. Clinical bidimensional measurement of the lesion were performed at baseline, 6th week, and 3rd month. Incisional punch biopsy was performed at baseline and at the end of the 3rd month. The primary outcome analyzed was the clinical measurement of the lesion and histopathological response at the end of the 3 months. An independent sample t-test was utilized to compare the means of clinical measurements between the oak gall and Triphala groups. Repeated measures analysis of variance (ANOVA) was carried out to analyze the mean reduction in the size of the lesion at the three time periods. Results: A total of 21 subjects completed the trial with a high clinical response rate (70%) in the Triphala group compared to the oak gall group (45.5%). The within-group comparison revealed a significant reduction in the size of the lesion over the period in both groups (p = 0.003). The difference in the clinical response between the oak gall and Triphala groups was not statistically significant (p = 0.444). A Chi-squared test was done to compare the histopathological responses, which proved that there is no statistical difference in the histopathological response between the two treatment groups (p = 1.000). The histopathological response revealed a complete reversal of leukoplakia in two patients in both groups. Conclusion: Oak gall oil and Triphala oil can be used as an adjuvant in the management of oral leukoplakia. Both oak gall and Triphala groups have shown significant reduction in the size of the lesion clinically but not complete reversal of the lesion histopathologically, owing to the limited period of the trial. Clinical significance: Indigenous plant products such as oak gall and Triphala oil can serve as simple, safe, and culturally acceptable adjuvants in the management of oral leukoplakia. The exact mechanism of action of oak gall oil and Triphala oil against free radicals should be thoroughly studied to introduce targeted therapies against oral leukoplakia. Clinical trial registration number: CTRI/2016/10/007415.