Keywords :
Anemia, Gut hormones, Periomedicine, Periodontal diseases
Citation Information :
Santhanakrishnan S, Ari G, Rajendran S, Mahendra J, Namasivayam A. Expression of Serum and Salivary Levels of Obestatin in Periodontitis Patients with and without Iron Deficiency Anemia. World J Dent 2024; 15 (7):625-629.
Aim and background: To evaluate and correlate the serum and salivary obestatin levels in periodontitis patients with and without iron deficiency anemia (IDA).
Materials and methods: A total of 30 patients needed for this study were recruited from the Institutional Outpatient Department of Periodontology and were divided into three groups—group periodontitis (P) had 10 patients with only periodontitis, group IDA had 10 patients with only IDA, and group iron deficiency anemia + periodontitis (IDA + P) had 10 patients with both periodontitis and IDA. After recording the periodontal parameters, the serum and saliva samples were collected, and the obestatin levels were estimated using an enzyme-linked immunosorbent assay (ELISA) kit.
Results: Group IDA + P, when compared to group IDA and group P, showed higher mean values of plaque index (PI), modified gingival index (MGI), probing depth (PD) and clinical attachment levels (CALs). In comparison with the other two groups, in patients with periodontitis in group P, serum and salivary obestatin mean values were increased. A statistically significant strong positive Spearman correlation between the serum and salivary levels of obestatin, as well as between PD and CALs, was found.
Conclusion: Our findings are suggestive that the serum and salivary levels of obestatin could serve as a potential biomarker of IDA and periodontal disease. Thus, further research is needed to explore the underlying mechanism and understand the relationship between this marker and periodontitis.
Clinical significance: In patients with periodontitis and IDA, the serum and salivary obestatin levels could serve as potential biomarkers, thus indicating the progression of these chronic diseases.
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