A Comparative Clinical and Microbiological Evaluation of Arimedadi Oil with 0.2% Chlorhexidine Mouthwash as an Adjuvant to Scaling in Chronic Gingivitis
Umme Kulsum, Vinita Boloor, I V Rao, Rajesh K S, Akshatha K Bhat, Shashikanth Hegde
Keywords :
Aerobic colony forming units, Arimedadi oil, Chlorhexidine antiseptic drug delivery system mouthwash, Herbal mouthwashes, Management of gingivitis, Polyherbal mouthwash
Citation Information :
Kulsum U, Boloor V, Rao IV, K S R, Bhat AK, Hegde S. A Comparative Clinical and Microbiological Evaluation of Arimedadi Oil with 0.2% Chlorhexidine Mouthwash as an Adjuvant to Scaling in Chronic Gingivitis. World J Dent 2024; 15 (5):429-435.
Aim: The aim of the present study is to comparatively evaluate the clinical and microbiological efficacy of Arimedadi oil and 0.2% chlorhexidine (CHX) gluconate mouthwash as an adjuvant to scaling in chronic gingivitis.
Materials and methods: A total of 45 subjects were randomly divided into three groups, that is, group I (scaling alone), group II [scaling + adjunctive use of 0.2% CHX antiseptic drug delivery system (ADS) mouthwash], and group III (scaling + adjunctive use of Arimedadi oil) over a period of 21 days. Plaque index (PI) and gingival index (GI) were measured at baseline, 14th day, and 21st day, and the number of aerobic colony-forming units (CFU) was evaluated at baseline and 21st day.
Results: There was a statistically significant reduction of GI (p-value of 0.00), PI (p-value of 0.00), and number of CFU (p-value of 0.04) in groups II and III over a period of 21 days. However, on intergroup comparison, the reduction of PI was greater in group II on the 14th day (p-value of 0.042), whereas group III was as effective as group II in the reduction of PI, GI, and number of CFU on the 21st day (p-value of 0.00).
Conclusion: Arimedadi oil is as effective as CHX in preventing plaque formation and gingival inflammation, as well as reducing the number of aerobic CFUs.
Clinical significance: The preventive and therapeutic advantages of polyherbal products such as Arimedadi oil are a reliable and potentially secure substitute for CHX mouthwash.
Trombelli L, Farina R, Silva CO, et al. Plaque-induced gingivitis: case definition and diagnostic considerations. J Clin Periodontol 2018;45(Suppl 20):S44–S67. DOI: 10.1111/jcpe.12939
Löe H, Anerud A, Boysen H, et al. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol 1986;13(5):431–445. DOI: 10.1111/j.1600-051x.1986.tb01487.x
Ismail AI, Morrison EC, Burt BA, et al. Natural history of periodontal disease in adults: findings from the Tecumseh Periodontal Disease Study, 1959–87. J Dent Res 1990;69(2):430–435. DOI: 10.1177/00220345900690020201
Clerehugh V, Worthington HV, Lennon MA, et al. Site progression of loss of attachment over 5 years in 14- to 19-year-old adolescents. J Clin Periodontol 1995;22(1):15–21. DOI: 10.1111/j.1600-051x.1995.tb01766.x
Albandar JM, Kingman A, Brown LJ, et al. Gingival inflammation and subgingival calculus as determinants of disease progression in early-onset periodontitis. J Clin Periodontol 1998;25(3):231–237. DOI: 10.1111/j.1600-051x.1998.tb02433.x
Schätzle M, Löe H, Bürgin W, et al. Clinical course of chronic periodontitis. I. Role of gingivitis. J Clin Periodontol 2004;30(10):887–901. DOI: 10.1034/j.1600-051x.2003.00414.x
Ramseier CA, Anerud A, Dulac M, et al. Natural history of periodontitis: disease progression and tooth loss over 40 years. J Clin Periodontol 2017;44(12):1182–1191. DOI: 10.1111/jcpe.12782
Theilade E, Wright WH, Jensen SB, et al. Experimental gingivitis in man: II. A longitudinal clinical and bacteriological investigation. J Periodontal Res 1966;1(1):1–3. DOI: 10.1111/j.1600-0765.1966.tb01842.x
Serrano J, Escribano M, Roldan S, et al. Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: a systematic review and meta-analysis. J Clin Periodontol 2015;42(Suppl 16):S106–S138. DOI: 10.1111/jcpe.12331
Paraskevas S. Randomized controlled clinical trials on agents used for chemical plaque control. Int J Dent Hyg 2005;3:162–178. DOI: 10.1111/j.1601-5037.2005.00145.x
Moran J, Addy M, Wade WG, et al. A comparison of delmopinol and chlorhexidine on plaque regrowth over a 4-day period and salivary bacterial counts. J Clin Peri odontol 1992;19(10):749–753. DOI: 10.1111/j.1600-051x.1992.tb02165.x
Jenkins S, Addy M, Wade W, et al. The magnitude and duration of the effects of some mouthrinse products on salivary bacterial counts. J Clin Periodontol 1994;21(6):397–401. DOI: 10.1111/j.1600-051x.1994.tb00736.x
Elworthy A, Greenman J, Doherty FM, et al. The substantivity of a number of oral hygiene products determined by the duration of effects on salivary bacteria. J Periodontol 1996;67(6):572–576. DOI: 10.1902/jop.1996.67.6.572
Balbuena L, Stambaugh KI, Ramirez SG, et al. Effects of topical oral antiseptic rinses on bacterial counts of saliva in healthy human subjects. Otolaryngol Head Neck Surg 1998;118(5):625–629. DOI: 10.1177/019459989811800510
Tsuchiya H, Miyazaki T, Ohmoto S. High-performance liquid chromatographic analysis of chlorhexidine in saliva after mouthrinsing. Caries Res 1999;33(2):156–163. DOI: 10.1159/000016510
König J, Storcks V, Kocher T, et al. Anti-plaque effect of tempered 0.2% chlorhexidine rinse: an in vivo study. J Clin Periodontol 2002;29(3):207–210. DOI: 10.1034/j.1600-051x.2002.290304.x
Schiott CR, Löe H, Jensen SB, et al. The effect of chlorhexidine mouthrinses on the human oral flora. J Periodontal Res 1970;5(2):84–89. DOI: 10.1111/j.1600-0765.1970.tb00697.x
Claydon N, Addy M, Jackson R, et al. Studies on the effect of polyvinyl pyrrolidone on the activity of chlorhexidine mouthrinses: plaque and stain. J Clin Periodontol 2001;28(6):558–564. DOI: 10.1034/j.1600-051x.2001.028006558.x
Pereira R, Phad SG. Comparative evaluation of 0.2% chlorhexidine mouthrinse with and without an antidiscoloration system: a clinical study. J Contemp Dent 2017;7(1):53–56. DOI: 10.5005/jp-journals-10031-1185
Hussain H, Jan SM, Behal R. Chlorhexidine mouth rinse with a plasdone based anti-discolouration system for maintenance after periodontal flap surgery: a comparative clinical study. Int Arch Integr Med 2019;6(5):124–131. Retrieved from: https://www.iaimjournal.com/volume-6-issue-5-may-2019
Laleman I, Teughels W. Novel natural product-based oral topical rinses and toothpastes to prevent periodontal diseases. Periodontol 2000 2020;84(1):102–123. DOI: 10.1111/prd.12339
Mali GV, Dodamani AS, Karibasappa GN, et al. Comparative evaluation of arimedadi oil with 0.2% chlorhexidine gluconate in prevention of plaque and gingivitis: a randomized clinical trial. J Clin Diagn Res 2016;10(7):31–34. DOI: 10.7860/JCDR/2016/19120.8132
Sen GD, Mishra S (Eds). Bhasiajya Ratnavali. Chapter 61, Mukharogadhikar; Irimedaditaila, slok no. 129–133.
Dwivedi RB, Deole YS, Basisht G (Eds). Charak Samhita. Sutrasthana to Indriyasthana. Jamnagar: Ind; 2020. p. 2.
Amruthesh S. Dentistry and Ayurveda - IV: classification and management of common oral diseases. Indian J Dent Res 2008;19(1):52–61. DOI: 10.4103/0970-9290.38933
Boloor VA, Hosadurga R, Rao A, et al. Unconventional dentistry in India - an insight into the traditional methods. J Tradit Complement Med 2014;4(3):153–158. DOI: 10.4103/2225-4110.130951
Patil S, Varma SA, Suragimath G, et al. Evaluation of Irimedadi Taila as an adjunctive in treating plaque-induced gingivitis. J Ayurveda Integr Med 2018;9(1):57–60. DOI: 10.1016/j.jaim.2017.06.006
Jones CG. Chlorhexidine: is it still the gold standard?. Periodontology 2000 1997;15:55–62. DOI: 10.1111/j.1600-0757.1997.tb00105.x
Marsh PD. Microbiological aspects of the chemical control of plaque and gingivitis. J Dent Res 1992;71(7):1431–1438. DOI: 10.1177/00220345920710071501
Axelsson P, Lindhe J. Efficacy of mouthrinses in inhibiting dental plaque and gingivitis in man. J Clin Periodontal 1987;14(4):205–212. DOI: 10.1111/j.1600-051x.1987.tb00968.x
Graziani F, Gabriele M, D'Aiuto F, et al. Dental plaque, gingival inflammation and tooth -discolouration with diKerent commercial -formulations of 0.2% chlorhexidine rinse: a double-blind randomised controlled clinical trial. Oral Health Prev Dent 2015;13(2):101–111. DOI: 10.3290/j.ohpd.a32827
Rao VMS, Kranthi J, Rao KS, et al. Arimedadi Taila, an alternative remedy in the management of dental diseases. Int J Innov Res Dev 2014;3(4):55–58. Retrieved from: https://www.internationaljournalcorner.com/index.php/ijird_ojs
Cai H, Chen J, Panagodage Perera NK, et al. Effects of herbal mouthwashes on plaque and inflammation control for patients with gingivitis: a systematic review and meta-analysis of randomised controlled trials. Evid Based Complement Alternat Med 2020;2020:2829854. DOI: 10.1155/2020/2829854
Liljemark WF, Fenner LJ, Bloomquist CG. In vivo colonization of salivary pellicle by Haemophilus, Actinomyces and Streptococcus species. Caries Res 1986;20(6):481–497. DOI: 10.1159/000260979
Nyvad B, Kilian M. Microbiology of the early colonization of human enamel and root surfaces in vivo. Scand J Dent Res 1987;95(5):369–380. DOI: 10.1111/j.1600-0722.1987.tb01627.x
Briner WW, Grossman E, Buckner RY, et al. Effect of chlorhexidine gluconate mouthrinse on plaque bacteria. J Periodont Res 1986;21(s16):44–52. DOI: 10.1111/j.1600-0765.1986.tb01514.x
Ainamo J. Control of plaque by chemical agents. J Clin Periodontol 1977;4(5):23–35. DOI: 10.1111/j.1600-051x.1977.tb00049.x
Saravanan D, Ramkumar S, Vineetha K. Effect of oil pulling with sesame oil on plaque-induced gingivitis: a microbiological study. J Orofacial Res 2013:3(3):175–180. Retrieved from: https://www.editorialmanager.in/index.php/ijofr/index
Schiöstt CR, Briner WW, Kirkland JJ, et al. Two years oral use of chlorhexidine in man: III. Changes in sensitivity of the salivary flora. J Periodont Res 1976;11(3):153–157. DOI: 10.1111/j.1600-0765.1976.tb00063.x