World Journal of Dentistry

Register      Login

VOLUME 15 , ISSUE 2 ( February, 2024 ) > List of Articles


Role of Alginate-based Scaffolds for Periodontal Regeneration of Intrabony Defects: A Systematic Review

Devika Bajpai, Jaiganesh Ramamurthy

Keywords : Alginate, Intrabony defects, Periodontitis, Periodontal regeneration, Polymers, Scaffold

Citation Information : Bajpai D, Ramamurthy J. Role of Alginate-based Scaffolds for Periodontal Regeneration of Intrabony Defects: A Systematic Review. World J Dent 2024; 15 (2):181-187.

DOI: 10.5005/jp-journals-10015-2367

License: CC BY-NC 4.0

Published Online: 02-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aim: This systematic review aims to evaluate the effectiveness of scaffolds based on alginate in the regeneration of intrabony defects in periodontal tissue. Materials and methods: A thorough exploration was conducted in databases such as “PubMed”, “Google Scholar”, “Cochrane Library”, and “Science Direct”, adhering to predefined eligibility criteria. Following meticulous screening, studies involving in vitro and in vivo assessments of alginate's efficacy as a scaffold were chosen for inclusion. Results: The eight chosen studies investigated the involvement of alginate-based scaffolds in the regeneration of periodontal tissues. Among these, five in vivo studies utilized histologic and histometric analyzes, while the remaining in vitro studies examined bone regeneration by assessing alkaline phosphatase activity (ALP) through various staining methods. Comparisons were made with other biopolymers, molecules, or stem cells. Across all eight studies, alginate scaffolds consistently demonstrated superior outcomes in terms of bone regeneration. Conclusion: Combining alginate with other biopolymers can enhance its regenerative efficacy. Therefore, future researchers should concentrate on integrating novel biopolymers for further improvement. Clinical significance: Scaffolds made from alginate possess the ability to restore tissue lost as a result of periodontitis, demonstrating significant clinical relevance.

PDF Share
  1. Könönen E, Gursoy M, Gursoy UK. Periodontitis: a multifaceted disease of tooth-supporting tissues. J Clin Med 2019;8(8):1135. DOI: 10.3390/jcm8081135
  2. Lazar V, Ditu LM, Curutiu C, et al. Impact of dental plaque biofilms in periodontal disease: Management and future therapy. Periodontitis: A Useful Reference. London, United Kingdom: InTech Open; 2017. pp. 11–42.
  3. Needleman I, Worthington HV, Giedrys-Leeper E, et al. WITHDRAWN: guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev 2019;5(5):CD001724. DOI: 10.1002/14651858.CD001724.pub3
  4. Bartold PM, Mcculloch CA, Narayanan AS, et al. Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology. Periodontol 2000 2000;24(1):253–269. DOI: 10.1034/j.1600-0757.2000.2240113.x
  5. Nyman S, Lindhe J, Karring T, et al. New attachment following surgical treatment of human periodontal disease. J Clin Periodontol 1982;9(4):290–296. DOI: 10.1111/j.1600-051x.1982.tb02095.x
  6. Needleman IG, Worthington HV, Giedrys-Leeper E, et al. Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev 2006;(2):CD001724. DOI: 10.1002/14651858.CD001724.pub2
  7. Moshaverinia A, Chen C, Akiyama K, et al. Alginate hydrogel as a promising scaffold for dental-derived stem cells: an in vitro study. J Mater Sci Mater Med 2012;23(12):3041–3051. DOI: 10.1007/s10856-012-4759-3
  8. Sahoo DR, Biswal T. Alginate and its applicationapplication to tissue engineering. App Sci 2021;3(1):30.
  9. Elango J, Selvaganapathy PR, Lazzari G, et al. Biomimetic collagen-sodium alginate-titanium oxide (TiO2) 3D matrix supports differentiated periodontal ligament fibroblasts growth for periodontal tissue regeneration. Int J Biol Macromol 2020;163:9–18. DOI: 10.1016/j.ijbiomac.2020.06.173
  10. Chang PC, Lin ZJ, Luo HT, et al. Degradable RGD-functionalized 3D-printed scaffold promotes osteogenesis. J Dent Res 2021;100(10):1109–1117. DOI: 10.1177/00220345211024634
  11. Chen L, Shen R, Komasa S, et al. Drug-loadable calcium alginate hydrogel system for use in oral bone tissue repair. Int J Mol Ences 2017;18(5):989. DOI: 10.3390/ijms18050989
  12. Duruel T, Çakmak AS, Akman A, et al. Sequential IGF-1 and BMP-6 releasing chitosan/alginate/PLGA hybrid scaffolds for periodontal regeneration. Int J Biol Macromol 2017;104(Pt A):232–241. DOI: 10.1016/j.ijbiomac.2017.06.029
  13. He H, Huang J, Ping F, et al. Calcium alginate film used for guided bone regeneration in mandible defects in a rabbit model. CRANIO 2008;26(1):65–70. DOI: 10.1179/crn.2008.009
  14. Srinivasan S, Jayasree R, Chennazhi KP, et al. Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration. Carbohydr Polym 2012;87(1):274–283. DOI: 10.1016/j.carbpol.2011.07.058
  15. Wang B, Mastrogiacomo S, Yang F, et al. Application of BMP-Bone cement and FGF-Gel on periodontal tissue regeneration in nonhuman primates. Tissue Eng Part C Methods 2019;25(12):748–756. DOI: 10.1089/ten.TEC.2019.0160
  16. Weng Y, Wang M, Liu W, et al. Repair of experimental alveolar bone defects by tissue-engineered bone. Tissue Eng 2006;12(6):1503–1513. DOI: 10.1089/ten.2006.12.1503
  17. Raja S, Byakod G, Pudakalkatti P. Growth factors in periodontal regeneration. Int J Dent Hyg 2009;7(2):82–89. DOI: 10.1111/j.1601-5037.2009.00380.x
  18. Vinel A, Al Halabi A, Roumi S, et al. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches. Adv Exp Med Biol 2022;1373:303–327. DOI: 10.1007/978-3-030-96881-6_16
  19. Lee KY, Mooney DJ. Alginate: properties and biomedical applications. Prog Polym Sci 2012;37(1):106–126. DOI: 10.1016/j.progpolymsci.2011.06.003
  20. Liao J, Li Y, Li H, et al. Preparation, bioactivity and mechanism of nano-hydroxyapatite/sodium alginate/chitosan bone repair material. J Appl Biomater Funct Mater 2018;16(1):28–35. DOI: 10.5301/jabfm.5000372
  21. Donzelli E, Salvade A, Mimo P, et al. Mesenchymal stem cells cultured on a collagen scaffold: In vitro osteogenic differentiation. Arch Oral Biol 2007;52(1):64–73. DOI: 10.1016/j.archoralbio.2006.07.007
  22. Atia GAN, Shalaby HK, Zehravi M, et al. Drug-loaded chitosan scaffolds for periodontal tissue regeneration. Polymers (Basel) 2022;14(15):3192. DOI: 10.3390/polym14153192
  23. Vo TN, Kasper FK, Mikos AG. Strategies for controlled delivery of growth factors and cells for bone regeneration. Adv Drug Deliv Rev 2012;64(12):1292–1309. DOI: 10.1016/j.addr.2012.01.016
  24. Shah AT, Zahid S, Ikram F, et al. Tri-layered functionally graded membrane for potential application in periodontal regeneration. Mater Sci Eng 2019;103:109812. DOI: 10.1016/j.msec.2019.109812
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.