Aim: The aim of the present study was to evaluate the effects of curcumin and tetracycline fibers as local drug delivery (LDD) agents in treating chronic periodontitis. Materials and methods: A total of 20 chronic periodontitis patients aged between 45 and 60 years were recruited for this study. Two sites were selected in each patient and randomly allocated to the tetracycline fiber group and curcumin group. At baseline, subgingival plaque samples were collected from both groups. After full-mouth scaling and root planing (SRP), 8.33 mg of tetracycline fibers and 2.5 gm of curcumin were placed subgingivally at each site. At 1 month and 3 months, subgingival plaque samples were collected again for microbiological analysis of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Tannerella forsythia (Tf). All data were collected and statistically analyzed. Results: When comparing the baseline to the third month, both the tetracycline and curcumin groups demonstrated a statistically significant decrease in periodontal pathogens [Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Tannerella forsythia (Tf)] in the form of colony-forming units (CFUs); however, an intergroup comparison revealed no statistically significant difference (p > 0.05). Conclusion: The present study concluded that curcumin significantly reduces the causative organisms of chronic periodontitis and can be used as an adjunct to tetracycline fibers. Clinical significance: Antibacterial drugs can eradicate pathogenic organisms that are not mechanically accessible. The goal of developing various local antimicrobial medication delivery agents is to maintain the target site's levels of crevicular fluid at an appropriate level while limiting systemic absorption. Tetracycline inhibits collagenase activity, collagen breakdown, as well as bone resorption. Hence, alternatives such as curcumin can be used as LDD agents.