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VOLUME 15 , ISSUE 1 ( January, 2024 ) > List of Articles

REVIEW ARTICLE

Exploring the Epigenetic Landscape—Insights from Epigenomics in Periodontitis and Stress-related Health Implications: A Review

Smrithi Vishakha Varma, Sheeja Saji Varghese, Sajan Velayudhan Nair

Keywords : Chronic stress, Deoxyribonucleic acid methylation, Epigenetics, Epigenome, Histone modification, Immune response, Periodontitis

Citation Information : Varma SV, Varghese SS, Nair SV. Exploring the Epigenetic Landscape—Insights from Epigenomics in Periodontitis and Stress-related Health Implications: A Review. World J Dent 2024; 15 (1):72-78.

DOI: 10.5005/jp-journals-10015-2353

License: CC BY-NC 4.0

Published Online: 20-02-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Background: The emerging field of epigenetics probes into the intricate modifications and information beyond the primary genetic code, investigating how gene function can be altered and inherited across cell generations without changes in deoxyribonucleic acid (DNA) sequences. This review specifically focuses on the epigenetic dimensions within two captivating areas—periodontitis and stress-related health implications. Aim: The aim of this literature review is to comprehensively delve into current research, shedding light on the interplay between epigenetics, oral health, and overall well-being. It particularly explores the epigenetic intricacies associated with periodontitis and stress-related conditions. Clinical significance: Despite the genetic complexity of periodontitis, the emergence of epigenetic biomarkers provides hope for early disease diagnosis and personalized management. Epigenetics, with established links to various diseases, including cancer, unfolds new therapeutic possibilities. While challenges persist in unraveling the intricacies of epigenetic regulation, it holds promise for advancing disease eradication, even for historically incurable conditions. Epigenetics stands as a hopeful avenue for treating stress-related disorders, although its full potential is still in the early stages of exploration.

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