Aim: The purpose of this study was to evaluate and compare the microtensile bond strength of Giomer resin (Shofu Beautifil II Refills) to dentin using eighth-generation dental adhesive (G-Premio Bond GC) and seventh-generation dental adhesive (BeautiBond bonding agent—Shofu). Materials and methods: A total of 30 anonymized premolars were used. Two groups with 15 samples were allocated to each group. In group I, the seventh-generation bonding agent was used, and in group II, the eighth-generation bonding agent was used by keeping Giomer resin as the common restorative material in both groups. Samples were prepared by exposing the coronal dentin using a high-speed diamond disk. Etching of the exposed coronal dentin was done using 37% phosphoric acid, following which application of bonding agent was applied respectively by following the instruction manual of the bonding agent. Three equal increments of Giomer resin restorative material were made as blocks on the dentin surface of the tooth by light curing each increment for 30–40 seconds. A 21-gauge ortho wire was inserted through the resin block. The specimens were mounted in a universal testing machine. The microtensile force was applied parallel to the long axis of each specimen until the specimen was deboned. The tensile load at which the fracture occurs was recorded. The microtensile bond strength value was recorded in units of Mega Pascal (MPa). The results were analyzed using an independent t-test. Results: There is a significant difference between the seventh- and eighth-generation bonding agents when bonded with Giomer resin (p < 0.05). The mean average force to debond Giomer from the eighth-generation bonding agent from the exposed dentin is 5.894 N. Whereas, to debond Giomer bonded with the seventh-generation bonding agent from the exposed dentin is 3.176 N. Hence, the result of the study shows that eighth-generation bonding agents have higher microtensile strength than the seventh-generation bonding agents when bonded with Giomer resin material. Conclusion: In this in vitro study, eighth-generation, and seventh-generation bonding agents’ microtensile strength was determined individually by using Giomer as the restorative material. It was proved that the eighth-generation bonding agents have better microtensile strength than seventh-generation bonding agents. Clinical significance: Choosing the parameter microtensile strength because the efficacy of dentin bonding agent is mainly evaluated by tensile or microtensile bond strength. In this study, it was proved that the eighth-generation bonding agent shows superior microtensile bond strength when compared to the seventh-generation bonding agent while employing Giomer as the restorative material. This study can help clinicians choose the best restorative material like Giomer, which is widely used for its good color matching, reduced microleakage, increased fluoride release, and bonding agent, which has higher strength.