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VOLUME 14 , ISSUE 5 ( May, 2023 ) > List of Articles


Effect of Full Mouth Disinfection on Serum Ferritin Level in Periodontitis Patients: An Interventional Study

Sowmya Suriyanarayanan, Jaideep Mahendra, LK Anitha, Sathish Rajendran, Sruthi Srinivasan, Ambalavanan Namasivayam

Keywords : Full mouth disinfection, Inflammation, Nonsurgical periodontal therapy, Periodontitis, Serum ferritin

Citation Information : Suriyanarayanan S, Mahendra J, Anitha L, Rajendran S, Srinivasan S, Namasivayam A. Effect of Full Mouth Disinfection on Serum Ferritin Level in Periodontitis Patients: An Interventional Study. World J Dent 2023; 14 (5):440-446.

DOI: 10.5005/jp-journals-10015-2226

License: CC BY-NC 4.0

Published Online: 02-08-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Aim: The aim of the present study was to assess the outcome of full-mouth disinfection (FMD) on serum ferritin levels from baseline (0 day) to 90th day in subjects with periodontitis. Materials and methods: A total of 28 periodontitis individuals were selected and randomly allocated into two study groups. The conventional staged scaling and root planing (CSSRP) group consisted of 14 subjects with stage II grade I periodontitis who were scheduled for CSSRP. The FMD group consisted of 14 subjects with stage II grade I periodontitis who were scheduled to undergo FMD. Modified gingival index (MGI), probing pocket depth (PPD), bleeding on probing (BOP), and clinical attachment level (CAL) were the periodontal parameters assessed in the present study, followed by the estimation of serum ferritin levels at baseline (0th day) and 90th day. Results: Increased serum ferritin levels were observed in both the CSSRP group and FMD group at baseline (0th day). On the 90th day, both groups showed a statistically significant decrease in serum ferritin levels following CSSRP and FMD. However, the FMD group showed an additional reduction of serum ferritin levels when compared to the CSSRP group. Serum ferritin was positively correlated with all the periodontal variables in both groups. Conclusion: The present research concluded that FMD showed marginal improvement in serum ferritin levels compared to conventional staged SRP, thus concluding that FMD has an additive effect on serum ferritin levels in decreasing the inflammatory burden. Clinical significance: Serum ferritin can be regarded as a potential diagnostic as well as a prognostic biomarker for assessing the inflammatory status of periodontitis following nonsurgical periodontal treatment (NSPT).

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