Citation Information :
Priyadharshini G, Gheena S, Ramani P, Rajeshkumar S, Ramalingam K. Assessment of Antimicrobial Efficacy and Cytotoxicity of Cocos nucifera and Triticum aestivum Combination Gel Formulation for Therapeutic Use. World J Dent 2023; 14 (5):414-418.
Aim: To assess the antimicrobial efficacy and cytotoxicity of Cocos nucifera (C. nucifera) and Triticum aestivum (T.aestivum) based oral gel formulations.
Materials and methods:Cocos nucifera (C. nucifera) and T. aestivum based oral gel preparation was formulated. Antimicrobial activity was assessed against bacterial strains of Streptococcus mutans (S. mutans), Escherichia coli (E. coli), Bacillus, and Staphylococcus aureus (S. aureus) and a brine shrimp lethality assay was performed to assess the cytotoxicity.
Results: The antimicrobial activity was comparable to that of the control (amoxicillin), with the highest zone of inhibition of 13 mm at 100 µL. The cytotoxic effects were noted only at higher concentrations.
Conclusion: The oral gel formulation has the cumulative effect of both herbs with potent antimicrobial activity and less cytotoxicity.
Clinical significance: The herbal gel formulation can be used as an alternative to established medications for the treatment of oral inflammatory lesions and infectious pathologies.
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