Aim: To evaluate and compare sorption and solubility of traditional glass ionomer luting cement, resin-modified glass ionomer luting cement, and resin luting cement in distilled water (control group) and artificial saliva at varied time intervals at 37°C. Materials and method: Sixty disk-shaped specimens, divided into 20 specimens each, were fabricated with traditional glass ionomer luting cement, resin-modified glass ionomer luting cement, and resin luting cement, respectively, using a plastic mold. Ten specimens each from the respective groups were immersed in distilled water and artificial saliva, respectively. These specimens were assessed at time interval of 1 day, 1 week, 2 weeks, 3 weeks, and 4 weeks to evaluate sorption and solubility, during which period they were kept in the incubator and desiccator, respectively. The results were recorded, tabulated, and subjected to statistical analysis. Results: Conventional glass ionomer luting cement (GC Gold Label 1) showed the highest solubility followed by resin-modified glass ionomer luting cement (RelyX Luting 2) and the least soluble was resin-luting cement (Maxcem Elite). The interaction between the luting cement and storage media was statistically significant. Conclusion: The composition of the luting cement and the storage media significantly affected the sorption and solubility rate in the studied luting cements. Clinical significance: Water sorption and solubility of dental luting cements have a great clinical significance that cannot be overlooked. The extensive amount of solubility and sorption of luting cements in turn affects their durability and clinical performance. It may lead to reduced strength of the cement and eventually failure of the fixed dental prosthesis.