Aim: To evaluate and compare marginal integrity and casting defects using indirect sprue design, clockwise sprue design, and anticlockwise spiral sprue design. Materials and methods: A total of 60 wax patterns for casting were milled, simulating a single unit fixed dental prosthesis. They were randomly divided into the indirect spruing technique group (n = 20), clockwise spiral spruing technique group (n = 20) and anticlockwise spiral spruing technique group (n = 20). Test samples were then placed on the nickel–chromium (Ni–Cr) master die and checked for marginal fit under a stereomicroscope. Completeness of casting was checked visually. The comparison of mean values of marginal fit (in microns) between all three groups was done by applying student's unpaired ‘t’-test at 5% (p = 0.05) and 1% (p = 0.01) level of significance. Results: Mean marginal values of 135.73, 116.73, and 100.01 were found for indirect, clockwise spiral, and anticlockwise spiral sprue design, respectively. A statistically significant difference was seen in the mean marginal values between the spiral spruing technique—clockwise and anticlockwise—and the indirect group, while there was no significant difference between the clockwise spiral and anticlockwise spiral sprue technique. There was no statistically significant difference in the completeness of casing between all three groups. Conclusion: Indirect spruing technique, clockwise spiral spruing technique, and anticlockwise spiral spruing technique can be used in the laboratory for the fabrication of prosthesis as all the samples showed a marginal gap that was acceptable. Clinical significance: The spiral spruing technique reduces the marginal discrepancy in comparison to other spruing techniques. The direction in which the spiral is created has the least amount of significance in relation to casting defects and marginal discrepancy. Less amount of marginal discrepancy leads to a reduced amount of plaque accumulation and, in turn, increases the longevity of the prosthesis.